{"id":22417,"date":"2003-04-04T00:00:00","date_gmt":"2003-04-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/clonado-caracterizacion-molecular-y-expresion-de-la-adn-topoisomerasa-i-de-leishmania-donovani\/"},"modified":"2003-04-04T00:00:00","modified_gmt":"2003-04-04T00:00:00","slug":"clonado-caracterizacion-molecular-y-expresion-de-la-adn-topoisomerasa-i-de-leishmania-donovani","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/leon\/clonado-caracterizacion-molecular-y-expresion-de-la-adn-topoisomerasa-i-de-leishmania-donovani\/","title":{"rendered":"Clonado, caracterizaci\u00f3n molecular y expresi\u00f3n de la adn topoisomerasa i de leishmania donovani"},"content":{"rendered":"<h2>Tesis doctoral de <strong> H\u00e9ctor Villa Gonz\u00e1lez <\/strong><\/h2>\n<p>La leishmaniosis es una enfermedad parasitaria que afecta a unos doce millones de personas, distribuy\u00e9ndose principalmente en pa\u00edses en desarrollo. su agente etiol\u00f3gico, el protozoo leishmania, posee dos formas totalmente diferenciadas morfol\u00f3gica y fisiol\u00f3gicamente, el promastigote y el amastigote, que permiten su supervivencia en el mosquito vector en el hospedador vertebrado respectivamente. Biol\u00f3gicamente presenta ciertas peculiaridades, entre las que se encuentra un disco situado en la \u00fanica mitocondria existente y que se conoce como kinetoplasto.  se trata de un org\u00e1nulo que posee adn organizado en una serie de c\u00edrculos de diferente tama\u00f1o unidos entre s\u00ed a modo de malla.  la leishmaniosis presenta diversas formas cl\u00ednicas, desde procesos asintom\u00e1ticos hasta otros con gran afectaci\u00f3n visceral.  existen diversos tratamientos para la enfermedad, pero presentan problemas de toxicidad para el paciente y la aparici\u00f3n de resistencias. Adem\u00e1s no existe todav\u00eda una vacuna eficaz para el tratamiento preventivo, con lo que el desarrollo de nuevos compuestos eficaces se plantea urgente para el futuro m\u00e1s inmediato.  las adn topoisomerasas son enzimas que modifican el estado topol\u00f3gico del adn, siendo clave en procesos como la replicaci\u00f3n, la transcripci\u00f3n y la recombinaci\u00f3n g\u00e9nica. Su uso como dianas terap\u00e9uticas en el tratamiento de procesos patol\u00f3gicos de tipo proliferativo ha experimentado un gran desarrollo en los \u00faltimos a\u00f1os, ya que varios f\u00e1rmacos antitumorales y antibi\u00f3ticos tienen como mecanismo de acci\u00f3n la inhibici\u00f3n de este tipo de enzimas. En este contexto la potencial importancia de las adn topoisomerasas para el desarrollo de nuevos tratamientos frente a la leishmaniosis se relaciona en parte con la existencia del kinetoplasto y avala el esfuerzo realizado por la comunidad cient\u00edfica para su conocimiento.  entre los resultados m\u00e1s destacables se encuentra el descubrimiento de que la enzima e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Clonado, caracterizaci\u00f3n molecular y expresi\u00f3n de la adn topoisomerasa i de leishmania donovani<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Clonado, caracterizaci\u00f3n molecular y expresi\u00f3n de la adn topoisomerasa i de leishmania donovani <\/li>\n<li><strong>Autor:<\/strong>\u00a0 H\u00e9ctor Villa Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosa Mar\u00eda Reguera Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Antonio Rojo vazquez <\/li>\n<li>Francisco Gamarro conde (vocal)<\/li>\n<li> Requena rolan\u00eda Jos\u00e9 m. (vocal)<\/li>\n<li>Luis Rivas l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de H\u00e9ctor Villa Gonz\u00e1lez La leishmaniosis es una enfermedad parasitaria que afecta a unos doce millones de personas, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[4430],"tags":[3216,3371,67032,22320,66909,66534],"class_list":["post-22417","post","type-post","status-publish","format-standard","hentry","category-leon","tag-francisco-antonio-rojo-vazquez","tag-francisco-gamarro-conde","tag-hector-villa-gonzalez","tag-luis-rivas-lopez","tag-requena-rolania-jose-m","tag-rosa-maria-reguera-torres"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22417"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22417\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}