{"id":22430,"date":"2003-04-04T00:00:00","date_gmt":"2003-04-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-oxidacion-de-protea%c2%adnas-implicadas-en-los-mecanismos-reguladores-de-la-apoptosis-bcl-2-y-ant-inducida-por-el-oxido-na%c2%adtrico-en-celulas-secretoras-de-insulina\/"},"modified":"2003-04-04T00:00:00","modified_gmt":"2003-04-04T00:00:00","slug":"papel-de-la-oxidacion-de-protea%c2%adnas-implicadas-en-los-mecanismos-reguladores-de-la-apoptosis-bcl-2-y-ant-inducida-por-el-oxido-na%c2%adtrico-en-celulas-secretoras-de-insulina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sevilla\/papel-de-la-oxidacion-de-protea%c2%adnas-implicadas-en-los-mecanismos-reguladores-de-la-apoptosis-bcl-2-y-ant-inducida-por-el-oxido-na%c2%adtrico-en-celulas-secretoras-de-insulina\/","title":{"rendered":"Papel de la oxidaci\u00f3n de prote\u00ednas implicadas en los mecanismos reguladores de la apoptosis (bcl-2 y ant) inducida por el \u00f3xido n\u00edtrico en c\u00e9lulas secretoras de insulina"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cahuana Macedo Gladys Margot <\/strong><\/h2>\n<p>Los estudios relacionados con los mecanismos moleculares de acci\u00f3n del \u00f3xido n\u00edtrico (no) son muy diversos; sin embargo, es mucho lo que se desconoce sobre ello. Un aspecto trascendental es su papel como modulador de la apoptosis. en otras tesis doctorales anteriormente realizadas en nuestro laboratorio se ha descrito que el no a elevadas concentraciones induce apoptosis en las c\u00e9lulas rinm5f. En esta tesis presentamos evidencia de que las acciones apopt\u00f3ticas del no est\u00e1n relacionadas mecan\u00edsticamente con su capacidad de oxidar l\u00edpidos y prote\u00ednas.  en la primera parte de la tesis mostramos que tanto el no generado end\u00f3genamente por inducci\u00f3n de la inos por acci\u00f3n de la il-1beta como el no derivado de donadores qu\u00edmicos inducen la formaci\u00f3n de productos finales de la peroxidaci\u00f3n de l\u00edpidos, siendo dicha peroxidaci\u00f3n disminu\u00edda significativamente por la super\u00f3xido dismutasa y la catalasa.  en la segunda parte dela tesis mostramos que dos prote\u00ednas importantes en el control de la apoptosis, bcl-2 y ant, son oxidadas por acci\u00f3n del no. Esta oxidaci\u00f3n est\u00e1 principalmente mediada por los productos finales de la lipoxidaci\u00f3n avanzada (ales) generados por el no, ya que tanto al aminoguanidina (ag) como la piridoxamina (pm), inhibidores de la formaci\u00f3n de los ales, cancelan la oxidaci\u00f3n producida por el no; asimismo, la ag y la pm disminuyen significativamente la apoptosis inducida por el no.  en la tercera parte de la tesis presentamos evicencias sobre el papel de la gapdh en la apoptosis inducida por el no. El no inhibe la actividad de la gapdh e induce su translocaci\u00f3n desde el citoplasma al n\u00facleo; estos efectos son dependientes de la formaci\u00f3n de los ales inducida por el no, ya que tanto la ag como la pm los cancelan.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la oxidaci\u00f3n de prote\u00ednas implicadas en los mecanismos reguladores de la apoptosis (bcl-2 y ant) inducida por el \u00f3xido n\u00edtrico en c\u00e9lulas secretoras de insulina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la oxidaci\u00f3n de prote\u00ednas implicadas en los mecanismos reguladores de la apoptosis (bcl-2 y ant) inducida por el \u00f3xido n\u00edtrico en c\u00e9lulas secretoras de insulina <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cahuana Macedo Gladys Margot <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Bedoya Bergua<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ramon Bartrons bach <\/li>\n<li>consuelo Santamar\u00eda p\u00e9rez (vocal)<\/li>\n<li>Francisco Sobrino beneyto (vocal)<\/li>\n<li>Francisco Mart\u00edn bermudo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cahuana Macedo Gladys Margot Los estudios relacionados con los mecanismos moleculares de acci\u00f3n del \u00f3xido n\u00edtrico (no) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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