{"id":22458,"date":"2003-05-04T00:00:00","date_gmt":"2003-05-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-proliferacion-celular-y-variaciones-fenota%c2%adpicas-de-las-celulas-vipergicas-hipofisarias-inducidas-por-la-inmunosupresion-de-la-interleucina-6\/"},"modified":"2003-05-04T00:00:00","modified_gmt":"2003-05-04T00:00:00","slug":"estudio-de-la-proliferacion-celular-y-variaciones-fenota%c2%adpicas-de-las-celulas-vipergicas-hipofisarias-inducidas-por-la-inmunosupresion-de-la-interleucina-6","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/estudio-de-la-proliferacion-celular-y-variaciones-fenota%c2%adpicas-de-las-celulas-vipergicas-hipofisarias-inducidas-por-la-inmunosupresion-de-la-interleucina-6\/","title":{"rendered":"Estudio de la proliferaci\u00f3n celular y variaciones fenot\u00edpicas de las c\u00e9lulas vip\u00e9rgicas hipofisarias inducidas por la inmunosupresi\u00f3n de la interleucina 6"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Herrero Ant\u00f3n Rosa M. <\/strong><\/h2>\n<p>En nuestro estudio se determin\u00f3 la influencia que la interleucina 6 ejerce sobre la proliferaci\u00f3n de las c\u00e9lulas vip\u00e9rgicas hipofisarias y las modificaciones fenot\u00edpicas que se provocaron en cada una de ellas.  para poder determinar el efecto de dicha interleucina sin interferencias de factores u hormonas, centrales o perif\u00e9ricas, se desarroll\u00f3 un estudio \u00abin vitro\u00bb sobre cultivos monocapa hipofisarios obtenidos a partir de hip\u00f3fisis de ratas adultas de la cepa wistar. Estos cultivos se sometieron, tras 7 d\u00edas de evoluci\u00f3n, a inmunosupresi\u00f3n mediante el tratamiento con anticuerpo antiinterleucina 6 y se estudiaron despu\u00e9s de 1, 3, 6 y 24 horas de incubaci\u00f3n.  los cambios fenot\u00edpicos se analizaron mediante las variaciones morfol\u00f3gicas y la cuantificaci\u00f3n de las c\u00e9lulas vip\u00e9rgicas.  los resultados que se obtuvieron demostraron que la inmunosupresi\u00f3n de la interleucina 6 provoca cambios significativos en el tama\u00f1o celular fundamentalmente a las 6 horas de tratamiento, ya que apreciamos una disminuci\u00f3n tanto del \u00e1rea citopl\u00e1smica como del \u00e1rea nuclear. Este hecho sugiere una inhibici\u00f3n de la s\u00edntesis del p\u00e9ptido.  se observaron adem\u00e1s patrones variables de intensidad de la reacci\u00f3n que se explicar\u00edan por la existencia de distintos momentos de actividad celular y quiz\u00e1s, la degradaci\u00f3n del p\u00e9ptido que ha sido retenido dentro de la c\u00e9lula.  la proliferaci\u00f3n de las c\u00e9lulas vip\u00e9rgicas se determin\u00f3 mediante dobel marcaje inmunocitoqu\u00edmico para pcna y vip. Se constat\u00f3 que la inmunosupresi\u00f3n hab\u00eda provocado un descenso significativo del porcentaje de c\u00e9lulas hipofisarias en cultivo que expresaban intranuclearmente el pcna.  en nuestro estudio se demuestra que la interleucina 6 es un importante regulador auto-paracrino fisiol\u00f3gico de la secreci\u00f3n y proliferaci\u00f3n de las c\u00e9lulas vip\u00e9rgicas hipofisarias.  adem\u00e1s nuestros resultados sugieren que la interleucina 6 y vip son dos elementos de una misma<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la proliferaci\u00f3n celular y variaciones fenot\u00edpicas de las c\u00e9lulas vip\u00e9rgicas hipofisarias inducidas por la inmunosupresi\u00f3n de la interleucina 6<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la proliferaci\u00f3n celular y variaciones fenot\u00edpicas de las c\u00e9lulas vip\u00e9rgicas hipofisarias inducidas por la inmunosupresi\u00f3n de la interleucina 6 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Herrero Ant\u00f3n Rosa M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Carretero Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Vazquez rodriguez <\/li>\n<li> Moro balb\u00e1s Jos\u00e9 Antonio (vocal)<\/li>\n<li>enrique Barbosa ayucar (vocal)<\/li>\n<li>gabriel Palomero dominguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Herrero Ant\u00f3n Rosa M. En nuestro estudio se determin\u00f3 la influencia que la interleucina 6 ejerce sobre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9386],"tags":[12475,9147,67128,9521,67129,2012],"class_list":["post-22458","post","type-post","status-publish","format-standard","hentry","category-salamanca","tag-enrique-barbosa-ayucar","tag-gabriel-palomero-dominguez","tag-herrero-anton-rosa-m","tag-jose-carretero-gonzalez","tag-moro-balbas-jose-antonio","tag-ricardo-vazquez-rodriguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22458","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22458"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22458\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22458"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22458"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22458"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}