{"id":22484,"date":"2003-07-04T00:00:00","date_gmt":"2003-07-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-factores-geneticos-asociados-a-la-expresion-de-la-apolipoprotea%c2%adna-e\/"},"modified":"2003-07-04T00:00:00","modified_gmt":"2003-07-04T00:00:00","slug":"estudio-de-los-factores-geneticos-asociados-a-la-expresion-de-la-apolipoprotea%c2%adna-e","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/zaragoza\/estudio-de-los-factores-geneticos-asociados-a-la-expresion-de-la-apolipoprotea%c2%adna-e\/","title":{"rendered":"Estudio de los factores gen\u00e9ticos asociados a la expresi\u00f3n de la apolipoprote\u00edna e"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Ga\u00f1an Jimenez <\/strong><\/h2>\n<p>La apolipoprote\u00edna e (apo e) humana sintetizada en macr\u00f3fago presenta un claro papel antiaterog\u00e9nico. En el presente trabajo se ha analizado la asociaci\u00f3n entre los polimorfismos del promotor y regi\u00f3n codificante del gen de apolipoprote\u00edna e con la enfermedad aterosclerosa. Se han analizado tres grupos de sujetos: enfermos coronarios, personas mayores de 65 a\u00f1os sin enfermedad coronaria descrita y un grupo de reci\u00e9n nacidos consecutivos y an\u00f3nimos. No se han encontrado diferencias estad\u00edsticamente significativas entre las frecuencias al\u00e9licas de los polimorfismos -491a\/t, -427t\/c y -219g\/t entre el grupo de enfermos coronarios y los otros grupos estudiados. las frecuencias en las isoformas del gen de apo e resultaron similares a las descritas en otros estudios en poblaci\u00f3n general espa\u00f1ola y de pa\u00edses mediterr\u00e1neos, nos observ\u00e1ndose frecuencias al\u00e9licas elevadas asociadas a enfermedad coronaria. En el grupo de personas mayores de 65 a\u00f1os se identificaron dos portadores de la mutaci\u00f3n e2(r136s), la cual se asocia a hipertrigliceridemia y un portador de la mutaci\u00f3n edl149, relacionada con hipercolesterolemia. en todos los grupos se encontr\u00f3 un fuerte desequilibrio de uni\u00f3n entre el polimorfismo -427 y los polimorfismos que codifican las isoformas de apo e. Sin embargo, los polimorfismos del promotor del gen de apo e no presentaron asociaci\u00f3n con los niveles de colesterol total, colesterol en ldl, colesterol en hdl y triglic\u00e9ridos en los grupos analizados. Al analizar los \u00edndices que describen las coronariograf\u00edas en pacientes coronarios, se encontr\u00f3 una asociaci\u00f3n entre el polimorfismo -491 y el \u00edndice de vasos mayores afectados con lesiones superiores al 50%.  el gen de apolipoprote\u00edan e se expresa principalmente en h\u00edgado, aunque tambi\u00e9n existe expresi\u00f3n en numerosos tejidos extrahep\u00e1ticos como cerebro, macr\u00f3fago, piel, bazo, tejido adiposo, test\u00edculos &#8230; Se ha descrito un elemento de uni\u00f3n al factor n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los factores gen\u00e9ticos asociados a la expresi\u00f3n de la apolipoprote\u00edna e<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los factores gen\u00e9ticos asociados a la expresi\u00f3n de la apolipoprote\u00edna e <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Ga\u00f1an Jimenez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Pocovi Mieras<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Carlos Rodriguez rey <\/li>\n<li>Jos\u00e9 Puzo foncillas (vocal)<\/li>\n<li>Fernando Civeira murillo (vocal)<\/li>\n<li>carmen Garces segura (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Ga\u00f1an Jimenez La apolipoprote\u00edna e (apo e) humana sintetizada en macr\u00f3fago presenta un claro papel antiaterog\u00e9nico. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[13610],"tags":[67180,62644,28892,10658,29050,10660],"class_list":["post-22484","post","type-post","status-publish","format-standard","hentry","category-zaragoza","tag-alberto-ganan-jimenez","tag-carmen-garces-segura","tag-fernando-civeira-murillo","tag-jose-carlos-rodriguez-rey","tag-jose-puzo-foncillas","tag-miguel-pocovi-mieras"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22484","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22484"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22484\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22484"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22484"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22484"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}