{"id":22514,"date":"2003-09-04T00:00:00","date_gmt":"2003-09-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-genetica-de-la-atpasa-f0f1-de-streptococcus-pneumoniae-blanco-de-accion-de-antimicrobianos\/"},"modified":"2003-09-04T00:00:00","modified_gmt":"2003-09-04T00:00:00","slug":"caracterizacion-genetica-de-la-atpasa-f0f1-de-streptococcus-pneumoniae-blanco-de-accion-de-antimicrobianos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-genetica-de-la-atpasa-f0f1-de-streptococcus-pneumoniae-blanco-de-accion-de-antimicrobianos\/","title":{"rendered":"Caracterizaci\u00f3n gen\u00e9tica de la atpasa f0f1 de streptococcus pneumoniae. blanco de acci\u00f3n de antimicrobianos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio  Javier Mart\u00edn Galiano <\/strong><\/h2>\n<p>Streptococcus pneumoniae es una de las bacterias pat\u00f3genas con mayor \u00edndice de mortalidad a escala mundial. Es uno de los principales agentes etiol\u00f3gicos de la neumon\u00eda, otitis media, bacteiremia y meningitis. El control de las patolog\u00edas que produce est\u00e1 dificultado por el gran porcentaje de aislados cl\u00ednicos resistentes a compuestos antimicrobianos y a que la efectividad de la vacunaci\u00f3n no es completa en los grupos de riesgo.  se observ\u00f3 un incremento en la actividad de la atpasa f0f1 de s.Pneumoniae en respuesta a la acidificaci\u00f3n del medio extracelular. La funci\u00f3n de esta enzima es la de expulsar protones cuando disminuye el ph del medio y forma parte de la respuesta de tolerancia al \u00e1cido de esta bacteria. Se observaron incrementos paralelos en la cantidad de esta enzima, su arnm y la actividad del promotor del oper\u00f3n que la codifica, por lo que la regulaci\u00f3n de esta enzima se ejerce a nivel de iniciaci\u00f3n de transcripci\u00f3n. Una mutaci\u00f3n en la caja -10 del promotor imped\u00eda la regulaci\u00f3n por ph por lo que podr\u00eda existir una secuencia de reconocimiento por parte de alg\u00fan factor regulador.  se demostr\u00f3 que esta enzima es el blanco primario de la mefloquina y una serie de compuestos relacionados ya que existe una relaci\u00f3n directa entre su capacidad antimicrobiana y su capacidad de inhibici\u00f3n de la enzima in vitro, seg\u00fan se observ\u00f3 utilizando una serie de mutantes con distinto grado de resistencia a la mefloquina. La mayor parte de estos mutantes se obtuvieron despu\u00e9s de transformar una cepa sensible con los genes que codifican la diana de la droga amplificados a partir de la misma cepa, demostr\u00e1ndose que los cambios eran consecuencia de la tasa de error de la adn polimerasa. este m\u00e9todo fue tambi\u00e9n de utilidad para obtener mutantes de resistencia a ciprofloxacina, rifampicina y estreptomicina, algunos de ellos no previamente descritos en s.Pneumoniae. Se caracteriz\u00f3 gen\u00e9ticamente un aislado cl\u00ednico del gru<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n gen\u00e9tica de la atpasa f0f1 de streptococcus pneumoniae. blanco de acci\u00f3n de antimicrobianos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n gen\u00e9tica de la atpasa f0f1 de streptococcus pneumoniae. blanco de acci\u00f3n de antimicrobianos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio  Javier Mart\u00edn Galiano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Gonz\u00e1lez De La Campa Adela<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cristina Casals carro <\/li>\n<li>paloma L\u00f3pez Garc\u00eda (vocal)<\/li>\n<li>ernesto \u00e1ngel Garc\u00eda l\u00f3pez (vocal)<\/li>\n<li>asunci\u00f3n Fenoll comes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Javier Mart\u00edn Galiano Streptococcus pneumoniae es una de las bacterias pat\u00f3genas con mayor \u00edndice de mortalidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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