{"id":22538,"date":"2003-10-04T00:00:00","date_gmt":"2003-10-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-sistema-del-oxido-na%c2%adtrico-en-el-sistema-nervioso-central-de-ratas-sometidas-a-hipoxia-hipobarica\/"},"modified":"2003-10-04T00:00:00","modified_gmt":"2003-10-04T00:00:00","slug":"el-sistema-del-oxido-na%c2%adtrico-en-el-sistema-nervioso-central-de-ratas-sometidas-a-hipoxia-hipobarica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-sistema-del-oxido-na%c2%adtrico-en-el-sistema-nervioso-central-de-ratas-sometidas-a-hipoxia-hipobarica\/","title":{"rendered":"El sistema del \u00f3xido n\u00edtrico en el sistema nervioso central de ratas sometidas a hipoxia hipob\u00e1rica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Manuel Encinas Perez <\/strong><\/h2>\n<p>El \u00f3xido n\u00edtrico est\u00e1 implicado en diversas fisiopatolog\u00edas del sistema nervioso central, especialmente en aquellas relacionadas con un descenso en la concentraci\u00f3n de ox\u00edgeno.  nuestra hip\u00f3tesis es que el \u00f3xido n\u00edtrico puede desempe\u00f1ar un papel importante en las respuestas del sistema nervioso central ante una hipoxia hipob\u00e1rica, y por lo tanto en la fisiopatolog\u00eda y los cuadros cl\u00ednicos relacionados con la exposici\u00f3n a grandes altitudes. La hipoxia hipob\u00e1rica induce la aparici\u00f3n de des\u00f3rdenes neuropsicol\u00f3gicos y disfunciones mentales tales como insomnio, cefalea, n\u00e1useas, mareo, desorientaci\u00f3n, descoordinaci\u00f3n motora y deficiencias en la memoria. Aunque los s\u00edntomas causados por la hipoxia hipob\u00e1rica est\u00e1 bien caracterizados, los mecanismos biol\u00f3gicos que subyacen a estas alteraciones no han sido estudiados en profundidad. por ello, hemos investigado el comportamiento del \u00f3xido n\u00edtrico en el cerebelo, la corteza cerebral, el caudado-putamen y el hipocampo (las \u00e1reas del sistema nervioso con mayor vulnerabilidad a la falta de ox\u00edgeno) de ratas adultas sometidas a hipoxia hipob\u00e1rica.  por medio de una c\u00e1mara hipob\u00e1rica experimental expusimos a ratas adultas a una altitud simulada de 8300 m durante 3 \u00f3 7 h. Procedi\u00e9ndose a su sacrificio despu\u00e9s de periodos de reoxigenaci\u00f3n que abarcaban desde 0 h a 20 d\u00edas.  de las \u00e1reas seleccionadas se tomaron muestras en las que se realizaron t\u00e9cnicas de actividad enzim\u00e1tica de la \u00f3xido n\u00edtrico sintasa, de western blotting y de inmunohistoqu\u00edmica para las isoformas neuronal e inducible de la \u00f3xido n\u00edtrico sintasa y para la nitrotirosina, as\u00ed como tinci\u00f3n histoqu\u00edmica dependiente de la actividad nadph-diaforasa.  dado que se encontraron cambios significativos tanto en la expresi\u00f3n y distribuci\u00f3n de la isoforma neuronal de la oxido n\u00edtrico sintasa, como en la formaci\u00f3n y localizaci\u00f3n de la nitrotirosina, concluimos que el sistema del \u00f3xido n\u00edtrico<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El sistema del \u00f3xido n\u00edtrico en el sistema nervioso central de ratas sometidas a hipoxia hipob\u00e1rica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El sistema del \u00f3xido n\u00edtrico en el sistema nervioso central de ratas sometidas a hipoxia hipob\u00e1rica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Manuel Encinas Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Rodrigo Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benjam\u00edn Fern\u00e1ndez ruiz <\/li>\n<li>Juan  angel Pedrosa raya (vocal)<\/li>\n<li>ricardo Mart\u00ednez murillo (vocal)<\/li>\n<li>Manuel Jos\u00e9 Gayoso rodriguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Manuel Encinas Perez El \u00f3xido n\u00edtrico est\u00e1 implicado en diversas fisiopatolog\u00edas del sistema nervioso central, especialmente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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