{"id":22666,"date":"2018-03-09T09:12:55","date_gmt":"2018-03-09T09:12:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/trasplante-de-hepatocitos-intrata%c2%admicos-como-inductores-de-tolerancia\/"},"modified":"2018-03-09T09:12:55","modified_gmt":"2018-03-09T09:12:55","slug":"trasplante-de-hepatocitos-intrata%c2%admicos-como-inductores-de-tolerancia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/trasplante-de-hepatocitos-intrata%c2%admicos-como-inductores-de-tolerancia\/","title":{"rendered":"Trasplante de hepatocitos intrat\u00edmicos como inductores de tolerancia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nieves Mula Rey <\/strong><\/h2>\n<p>El trasplante de hepatocitos constituye una alternativa al trasplante hep\u00e1tico. sin embargo, no evita los problemas de lainmunosupresi\u00f3n y las complicaciones y efectos secundarios derivados de la misma. En este trabajo hemos introducido una nueva localizaci\u00f3n anat\u00f3mica, el timo, como \u00f3rgano receptor de c\u00e9lulas alog\u00e9nicas hep\u00e1ticas y se ha estudiado su funcionalidad y morfolog\u00eda al o largo del tiempo (42 d\u00edas). Por otro lado, se quer\u00eda obviar la inmunosupresi\u00f3n cr\u00f3nica, para lo cual se procedia a un segundo implante en un \u00f3rgano muy estudiado a lo largo de toda la literatura como es el bazo (21 d\u00edas despu\u00e9s del implante en timo). En este segundo implante se estudiaba tambi\u00e9n la funcinalidad y la morfolog\u00eda de las c\u00e9lulas trasplantadas. En nuestro trabajo se empleaba solamente una dosis de inmunosupresi\u00f3n 24 horas previas al implante en timo.  el modelo empleado, es un modelo de error cong\u00e9nito del metabolismo (rtas gunn), que se asimila al s\u00edndrome de crigler-najjar en humanos. Se caracteriza por un aumento de la bilirrubina libre en sangre y un descenso de bilirrubina conjugada en bilis.  mediante los estudios de funcionalidad, hemos demostrado descensos en los niveles de bilirrubina libre s\u00e9rica y aumento de la bilirrubina conjugada en bilis en los animales trasplantados.  se estudiaron los cambios en las c\u00e9lulas linfoides, directamente implicas en el proceso del rechazo (cd4+ y cd8+), no observ\u00e1ndose cambios en sangre, minetras que en las poblaciones linfoides intrat\u00edmicas, se observ\u00f3 un cambio a las 72 horas.  como resumen , el timo es un \u00f3rgano que permite la supervivencia y funcionalidad de los hepatocios alog\u00e9ncios trasplantados, aunque no parece favorecer una tolerancia inmunol\u00f3gica sist\u00e9mica a un segundo implante intrabdominal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Trasplante de hepatocitos intrat\u00edmicos como inductores de tolerancia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Trasplante de hepatocitos intrat\u00edmicos como inductores de tolerancia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nieves Mula Rey <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Paloma Maganto Suarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Garcia  sancho martin <\/li>\n<li>Antonio Col\u00e1s vicente (vocal)<\/li>\n<li>rosa Mar\u00eda Arahuetes portero (vocal)<\/li>\n<li>Luis \u00e1lvarez vallina (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nieves Mula Rey El trasplante de hepatocitos constituye una alternativa al trasplante hep\u00e1tico. sin embargo, no evita [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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