{"id":22680,"date":"2018-03-09T09:12:56","date_gmt":"2018-03-09T09:12:56","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-piridazinofurocumarinas-analogos-nitrogenados-de-potentes-inhibidores-del-adn\/"},"modified":"2018-03-09T09:12:56","modified_gmt":"2018-03-09T09:12:56","slug":"sa%c2%adntesis-de-piridazinofurocumarinas-analogos-nitrogenados-de-potentes-inhibidores-del-adn","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sa%c2%adntesis-de-piridazinofurocumarinas-analogos-nitrogenados-de-potentes-inhibidores-del-adn\/","title":{"rendered":"S\u00edntesis de piridazinofurocumarinas: an\u00e1logos nitrogenados de potentes inhibidores del adn"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonz\u00e1lez G\u00f3mez Jos\u00e9 Carlos <\/strong><\/h2>\n<p>Las benzofurocumarinas son un grupo importante de intercalantes del adn que tienen gran utilidad en el tratamiento fotoquimioterap\u00e9utico de diferentes enfermedades hiperproliferativas de la piel (terapia puva). en el presente trabajo se aborda la s\u00edntesis de piridazinofurocumarinas, como an\u00e1logos nitrogenados de las benzofurocumarinas, esperando que este cambio isost\u00e9rico incremente la estabilidad del complejo de intercalaci\u00f3n f\u00e1rmaco-adn e influya en la especificidad de secuencia.  la etapa clave en la s\u00edntesis de las piridazinofurocumarinas consisti\u00f3 en la reacci\u00f3n de diels-alder entre derivados furocumar\u00ednicos (dien\u00f3filo) y 1,2,4,5-tetrazinas (dieno), consigui\u00e9ndose la fusi\u00f3n del anillo piridaz\u00ednico al anillo fur\u00e1nico en las posiciones (4,5-h) o (4,3-h) en dependencia de los sustituyentes presentes en la pareja dien\u00f3filo\/dieno. Teniendo en cuenta el mejor perfil farmacol\u00f3gico observado para las benzofurocumarinas lineales, se prest\u00f3 especial atenci\u00f3n al desarrollo de rutas que permitieran obtener regioselectivamente priidazinofurocumarinas lineales (piridazinopsoralenos). adem\u00e1s, se pusieron a punto metodolog\u00edas sint\u00e9ticas que permitieron la introducci\u00f3n de una o dos cadenas de diferente naturaleza a los sistemas poliarom\u00e1ticos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de piridazinofurocumarinas: an\u00e1logos nitrogenados de potentes inhibidores del adn<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de piridazinofurocumarinas: an\u00e1logos nitrogenados de potentes inhibidores del adn <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonz\u00e1lez G\u00f3mez Jos\u00e9 Carlos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eugenio Uriarte Villares<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felipe Alcudia gonzalez <\/li>\n<li>tom\u00e1s Tejero l\u00f3pez (vocal)<\/li>\n<li>Miguel Tom\u00e1s land\u00edes (vocal)<\/li>\n<li>Santiago Figueroa p\u00e9rez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonz\u00e1lez G\u00f3mez Jos\u00e9 Carlos Las benzofurocumarinas son un grupo importante de intercalantes del adn que tienen gran [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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