{"id":22695,"date":"2018-03-09T09:12:58","date_gmt":"2018-03-09T09:12:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicaciones-de-hidrazonas-e-hidracinas-quirales-sa%c2%adntesis-asimetrica-de-compuestos-14-dicarbona%c2%adlicos-y-beta-aminocarbona%c2%adlicos\/"},"modified":"2018-03-09T09:12:58","modified_gmt":"2018-03-09T09:12:58","slug":"aplicaciones-de-hidrazonas-e-hidracinas-quirales-sa%c2%adntesis-asimetrica-de-compuestos-14-dicarbona%c2%adlicos-y-beta-aminocarbona%c2%adlicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sevilla\/aplicaciones-de-hidrazonas-e-hidracinas-quirales-sa%c2%adntesis-asimetrica-de-compuestos-14-dicarbona%c2%adlicos-y-beta-aminocarbona%c2%adlicos\/","title":{"rendered":"Aplicaciones de hidrazonas e hidracinas quirales. s\u00edntesis asim\u00e9trica de compuestos 1,4-dicarbon\u00edlicos y beta-aminocarbon\u00edlicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Auxiliadora Prieto C\u00e1rdenas <\/strong><\/h2>\n<p>En esta tesis se han desarrollado metodolog\u00edas de s\u00edntesis asim\u00e9trica de diversos compuestos bifuncionales de inter\u00e9s.  en primer lugar, la reacci\u00f3n de adici\u00f3n nucleof\u00edlica de hidrazonas de formaldeh\u00eddo a alquilid\u00e9n malonatos representan la primera s\u00edntesis enantioselectiva conocida para la s\u00edntesis de derivados de semialdeh\u00eddos succ\u00ednicos sustitu\u00eddos. la combinaci\u00f3n de una alta eficiencia qu\u00edmica en las adiciones y las propiedades como agente de resoluci\u00f3n que presenta como auxiliar la (s)-2-(difenilmetoximetil)pirrolidina permite obtener productos enantiom\u00e9ricamente puros en una \u00fanica operaci\u00f3n y con buenos rendimientos. Adem\u00e1s de los aldeh\u00eddos libres que se obtienen por ozon\u00f3lisis, la transformaci\u00f3n alternativa del grupo hidrazono en los correspondientes ditioacetales permite, adem\u00e1s de la obtenci\u00f3n de una forma estable y protegida de estos semialdeh\u00eddos succ\u00ednicos, acceder a la s\u00edntesis de \u00e9steres beta-arilpropi\u00f3nicos enantiopuros. De forma an\u00e1loga, la adici\u00f3n de estos mismos reactivos a sustratos c\u00edclicos permite un acceso directo a varios tipos de compuestos 1,4-dicarbon\u00edlicos que aparecen como precursores directos de diversas familias de compuestos bioactivos.  una segunda contribuci\u00f3n de esta tesis doctoral consiste en el estudio de metodolog\u00edas alternativas para la s\u00edntesis estereoselectiva de compuestos beta-aminocarbon\u00edlicos. Para la consecuci\u00f3n de este objetivo se han investigado dos rutas de s\u00edntesis.  1,- adici\u00f3n de sililacetales de cetena a hidrazonas derivadas de la (2s,6s)-1-amino-2,5-difenilpiperidina catalizada por sc(otf)3. Destacan de este procedimiento las condiciones de reacci\u00f3n suaves y sencillas, no siendo necesaria la exclusi\u00f3n de agua del medio y la posibilidad de emplear hidrazonas derivadas de aldeh\u00eddos alif\u00e1ticos como sustratos, ya que \u00e9ste es el caso peor resuelto mediante metodolog\u00edas alternativas.  2,- adici\u00f3n de tipo aza-michael de hidrazinas quirales a a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicaciones de hidrazonas e hidracinas quirales. s\u00edntesis asim\u00e9trica de compuestos 1,4-dicarbon\u00edlicos y beta-aminocarbon\u00edlicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicaciones de hidrazonas e hidracinas quirales. s\u00edntesis asim\u00e9trica de compuestos 1,4-dicarbon\u00edlicos y beta-aminocarbon\u00edlicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Auxiliadora Prieto C\u00e1rdenas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosario Fernandez Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique D\u00edez barra <\/li>\n<li>david D\u00edez mart\u00edn (vocal)<\/li>\n<li>inmaculada Robina ramirez (vocal)<\/li>\n<li> Khira el wahabi noureddine (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Auxiliadora Prieto C\u00e1rdenas En esta tesis se han desarrollado metodolog\u00edas de s\u00edntesis asim\u00e9trica de diversos compuestos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10715],"tags":[2804,5451,43722,67700,67699,11339],"class_list":["post-22695","post","type-post","status-publish","format-standard","hentry","category-sevilla","tag-david-diez-martin","tag-enrique-diez-barra","tag-inmaculada-robina-ramirez","tag-khira-el-wahabi-noureddine","tag-m-auxiliadora-prieto-cardenas","tag-rosario-fernandez-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22695","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22695"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22695\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22695"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22695"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22695"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}