{"id":22701,"date":"2018-03-09T09:12:58","date_gmt":"2018-03-09T09:12:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-comparativo-de-los-efectos-de-dotarizina-y-flunarizina-sobre-la-viabilidad-celular-y-sus-mecanismos-de-accion\/"},"modified":"2018-03-09T09:12:58","modified_gmt":"2018-03-09T09:12:58","slug":"estudio-comparativo-de-los-efectos-de-dotarizina-y-flunarizina-sobre-la-viabilidad-celular-y-sus-mecanismos-de-accion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-comparativo-de-los-efectos-de-dotarizina-y-flunarizina-sobre-la-viabilidad-celular-y-sus-mecanismos-de-accion\/","title":{"rendered":"Estudio comparativo de los efectos de dotarizina y flunarizina sobre la viabilidad celular y sus mecanismos de acci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Miguel Novalbos Reina <\/strong><\/h2>\n<p>La migra\u00f1a o jaqueca es una patolog\u00eda, en muchos casos invalidante, que afecta al menos 12-15% de la poblaci\u00f3n. Uno de los f\u00e1rmacos m\u00e1s eficaces y m\u00e1s utilizados en la prolifaxis de los ataques de migra\u00f1a es la flunarizina. no obstante, presenta el inconveniente de que puede producir efectos adversos graves (efectos extrapiramidales) en los tratamientos prolongados. La dotarizina es una nueva piperazina similiar en estructura a la flunarizina.  ha sido desarrollada con el objetivo de conseguir una mayor eficacia en la profilaxis de la migra\u00f1a a trav\u00e9s de un mecanismo m\u00faltiple (antagonista de receptores 5ht2a y 5ht2c, y bloqueante de los canales de ca2+), y de reducir el riesgo de los efectos adversos de la flunarizina. En esta tesis se pretende evaluar los efectos neurot\u00f3xicos y neuroprotectores de la dotarizina, compar\u00e1ndola con la flunarizina en dos modelos celulares que remedan las caracter\u00edsticas, estructura y funci\u00f3n de las neuronas simp\u00e1ticas, como son las c\u00e9lulas cromafines bovinas y la l\u00ednea celular de neuroblastoma sh-sy5y. En ambos casos la dotarizina tiene menor efecto citot\u00f3xico que la flunarizina, siendo la muerte celular, que acontece por la exposici\u00f3n a estos f\u00e1rmacos, consecuencia de mecanismos necr\u00f3ticos y apopt\u00f3ticos. se analizaron varios factores que pod\u00edan estar mediando el efecto citot\u00f3xico de estos f\u00e1rmacos, observando que estaba relacionado con la presencia de suero bovino fetal en el medio de cultivos. El efecto citot\u00f3xico de la dotarizina est\u00e1 tambi\u00e9n mediado por la producci\u00f3n de radicales libres de ox\u00edgeno.  en cambio la muerte ocasionada por estos dos f\u00e1rmacos no est\u00e1 relacionada con la lipofilicidad de los f\u00e1rmacos ni con la concentraci\u00f3n de calcio extracelular.  con la dotorizina se observ\u00f3 que produc\u00eda un aumento en la concentraci\u00f3n de calcio citos\u00f3lico [ca2+] que no se observ\u00f3 con flunarizina. Este aumento era debido a la inhibici\u00f3n de la atpasa de ca2+ del ret\u00edculo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio comparativo de los efectos de dotarizina y flunarizina sobre la viabilidad celular y sus mecanismos de acci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio comparativo de los efectos de dotarizina y flunarizina sobre la viabilidad celular y sus mecanismos de acci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Miguel Novalbos Reina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Abad Santos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>Manuel Ort\u00edz de land\u00e1zuri busca (vocal)<\/li>\n<li>Antonio Rodr\u00edguez artalejo (vocal)<\/li>\n<li>pedro Zapater hern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Miguel Novalbos Reina La migra\u00f1a o jaqueca es una patolog\u00eda, en muchos casos invalidante, que afecta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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