{"id":22726,"date":"2018-03-09T09:13:00","date_gmt":"2018-03-09T09:13:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-glp-1-sobre-la-expresion-genica-del-glut2-y-glut4-y-mecanismo-de-su-accion-sobre-el-metabolismo-hepatico-de-la-glucosa\/"},"modified":"2018-03-09T09:13:00","modified_gmt":"2018-03-09T09:13:00","slug":"efecto-del-glp-1-sobre-la-expresion-genica-del-glut2-y-glut4-y-mecanismo-de-su-accion-sobre-el-metabolismo-hepatico-de-la-glucosa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-glp-1-sobre-la-expresion-genica-del-glut2-y-glut4-y-mecanismo-de-su-accion-sobre-el-metabolismo-hepatico-de-la-glucosa\/","title":{"rendered":"Efecto del glp-1 sobre la expresi\u00f3n g\u00e9nica del glut2 y glut4 y mecanismo de su acci\u00f3n sobre el metabolismo hep\u00e1tico de la glucosa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Araceli Redondo Garc\u00eda De Los \u00e1ngeles <\/strong><\/h2>\n<p>La administraci\u00f3n ex\u00f3gena de glp-1 ejerce un efecto regulador de la transcripci\u00f3n g\u00e9nica de los glucotransportadores glut2 y glut4 en tejidos extrapancre\u00e1ticos participantes en la homeostasis global de la glucosa-h\u00edgado, m\u00fasculo y grasa-, al menos en el estado diab\u00e9tico tipo2, lo cual podr\u00eda indicar la necesidad de la presencia de insulina para que el glp-1 active el proceso transcripcional. La acci\u00f3n estimuladora del glp-1 sobre la expresi\u00f3n de arnm de glut2 y glut4 puede ser un mecanismo mediante el cual, al menos enparte, el p\u00e9ptido ejerce su control sobre la glucemia.  el efecto estimulador del glp-1 sobre la gluc\u00f3geno sintasa a en el hepatocito parece suceder a trav\u00e9s de una v\u00eda de se\u00f1alizaci\u00f3n celular que implicar\u00eda la activaci\u00f3n de pi3k\/pkb, pkc, y s\u00f3lo en parte, la de pp-1 (a diferencia con la insulina), pero no la de pp-2a. El glp-1, adem\u00e1s, al igual que la insulina, estimula la fosforilaci\u00f3n de p42\/44 mapk y de p70s6k; estas enzimas, que no parecen intervenir en el efecto del p\u00e9ptido sobre la s\u00edntesis de gluc\u00f3geno, s\u00ed podr\u00edan participar en otras acciones del glp-1, distintas de aquellas relacionadas con el metabolismo hep\u00e1tico de la glucosa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del glp-1 sobre la expresi\u00f3n g\u00e9nica del glut2 y glut4 y mecanismo de su acci\u00f3n sobre el metabolismo hep\u00e1tico de la glucosa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del glp-1 sobre la expresi\u00f3n g\u00e9nica del glut2 y glut4 y mecanismo de su acci\u00f3n sobre el metabolismo hep\u00e1tico de la glucosa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Araceli Redondo Garc\u00eda De Los \u00e1ngeles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>pe\u00f1a Carrillo M. Luisa Villanueva<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jorgina Satr\u00fastegui gil-delgado <\/li>\n<li>isabel Valverde alonso (vocal)<\/li>\n<li>enrique Bl\u00e1zquez fern\u00e1ndez (vocal)<\/li>\n<li>Jos\u00e9 enrique Campillo \u00e1lvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Araceli Redondo Garc\u00eda De Los \u00e1ngeles La administraci\u00f3n ex\u00f3gena de glp-1 ejerce un efecto regulador de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[67774,3180,5536,6755,1743,67775],"class_list":["post-22726","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-araceli-redondo-garcia-de-los-angeles","tag-enrique-blazquez-fernandez","tag-isabel-valverde-alonso","tag-jorgina-satrustegui-gil-delgado","tag-jose-enrique-campillo-alvarez","tag-pena-carrillo-m-luisa-villanueva"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22726","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22726"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22726\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22726"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22726"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22726"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}