{"id":22748,"date":"2018-03-09T09:13:02","date_gmt":"2018-03-09T09:13:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificaciones-morfologicas-y-moleculares-de-la-envoltura-nuclear-y-la-maquinaria-de-transporte-nucleocitoplasmico-durante-el-proceso-de-activacion-linfocitaria\/"},"modified":"2018-03-09T09:13:02","modified_gmt":"2018-03-09T09:13:02","slug":"modificaciones-morfologicas-y-moleculares-de-la-envoltura-nuclear-y-la-maquinaria-de-transporte-nucleocitoplasmico-durante-el-proceso-de-activacion-linfocitaria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/modificaciones-morfologicas-y-moleculares-de-la-envoltura-nuclear-y-la-maquinaria-de-transporte-nucleocitoplasmico-durante-el-proceso-de-activacion-linfocitaria\/","title":{"rendered":"Modificaciones morfol\u00f3gicas y moleculares de la envoltura nuclear y la maquinaria de transporte nucleocitopl\u00e1smico durante el proceso de activaci\u00f3n linfocitaria"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raul Alonso Macho <\/strong><\/h2>\n<p>La envoltura nuclear rodea al material gen\u00e9tico en eucariotas y les permite unos niveles de regulaci\u00f3n de la expresi\u00f3n g\u00e9nica inexistentes en procariotas. por ejemplo, algunas rutas de transmisi\u00f3n de se\u00f1ales tienen una \u00faltima fase de amplificaci\u00f3n que depende de la translocaci\u00f3n al n\u00facleo de factores de transcripci\u00f3n o de quinasas que los modulan. En este sentido, la activaci\u00f3n linfocitaria en respuesta a un est\u00edmulo externo genera cambios en el patr\u00f3n de expresi\u00f3n g\u00e9nica que conllevan importantes modificaciones estructurales y funcionales a nivel nuclear. Para que tengan lugar todos estos cambios, es necesaria la participaci\u00f3n de la maquinaria de transporte nucleocitopl\u00e1smico a trav\u00e9s de la envoltura nuclear.  la presente tesis doctoral se centra en el estudio de las modificaciones bioqu\u00edmicas, estructurales y funcionales de la envoltura nuclear y del transporte nucleocitopl\u00e1smico durante el proceso de activaci\u00f3n linfocitaria. paralelamente, el uso de sueros procedentes de pacientes con enfermedades autoinmunes que reconocen componentes de la envoltura nuclear nos sirve no s\u00f3lo como herramienta de an\u00e1lisis \u00fatil para confirmar el diagn\u00f3stico cl\u00ednico, sino para profundizar en el propio conocimiento de estos ant\u00edgenos nucleares.  en este sentido, hemos podido observar que la mayor\u00eda de los sueros de pacientes con cirrosis biliar primaria que reaccionan contra la glicoprote\u00edna de la envoltura nuclear gp210 reconocen su extremo carboxilo citopl\u00e1smico.  por otra parte, y en relaci\u00f3n con los cambios de la envoltura nuclear durante la activaci\u00f3n linfocitaria, hemos detectado una respuesta diferente en la expresi\u00f3n tanto de componentes estructurales como de la maquinaria soluble de transporte nucleocitopl\u00e1smico. As\u00ed, hemos observado que los niveles de las laminas nucleares a y c y la importina alfa (rch1), una prote\u00edna que reconoce secuencias de localizaci\u00f3n nuclear presentes en prote\u00ednas cariof\u00edlicas, au<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificaciones morfol\u00f3gicas y moleculares de la envoltura nuclear y la maquinaria de transporte nucleocitopl\u00e1smico durante el proceso de activaci\u00f3n linfocitaria<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificaciones morfol\u00f3gicas y moleculares de la envoltura nuclear y la maquinaria de transporte nucleocitopl\u00e1smico durante el proceso de activaci\u00f3n linfocitaria <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raul Alonso Macho <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Miguel Ar\u00e9chaga Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Paniagua g\u00f3mez-\u00e1lvarez <\/li>\n<li>Antonio R\u00edos guadix (vocal)<\/li>\n<li> Calvo mart\u00edn Jos\u00e9 Luis (vocal)<\/li>\n<li> Ca\u00f1avate escribano Mar\u00eda  lux (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raul Alonso Macho La envoltura nuclear rodea al material gen\u00e9tico en eucariotas y les permite unos niveles [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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