{"id":2276,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/sintesis-quiral-de-beta-lactamas-precursoras-de-sistemas-1-metilcarbapenemicos\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"sintesis-quiral-de-beta-lactamas-precursoras-de-sistemas-1-metilcarbapenemicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sintesis-quiral-de-beta-lactamas-precursoras-de-sistemas-1-metilcarbapenemicos\/","title":{"rendered":"Sintesis quiral de beta-lactamas precursoras de sistemas 1-metilcarbapenemicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nieves Martin Laso <\/strong><\/h2>\n<p>En este trabajo se ha investigado la posible transformacion en un numero reducido de etapas de beta-lactamas monociclicas en los compuestos beta-lactamicos biciclicos 1-metilcarbapenemicos (analogos de tienamicina). Como estrategia sintetica se han utilizado la reaccion de staudinger empleando d-glucosamina como auxiliar quiral para la formacion de las beta-lactamas enantiomericamente puras y una reaccion de ciclacion radicalaria intramolecular para obtener el sistema biciclico carbapenamico, reaccion que ha resultado ser altamente regio- y diastereo-selectiva.  los compuestos carbapenamicos obtenidos, diferentemente funcionalizados sobre el carbono c-1, han sido transformados en sistemas 1-bencilcarbapenemicos (por degradacion oxidativa de la cadena de azucar) y en sistemas 1-metilcarbapenamicos (por de descarboxilacion radicalaria).  se han preparado tambien compuestos beta-lactamicos mono- y biciclicos convenientemente funcionalizados para estudiar su potencial actividad como inhibidores de la elastasa leucocitaria humana.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis quiral de beta-lactamas precursoras de sistemas 1-metilcarbapenemicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis quiral de beta-lactamas precursoras de sistemas 1-metilcarbapenemicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nieves Martin Laso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josefa Anaya Mateos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ines Sanchez Bellido <\/li>\n<li> Aizpurua Arbizu Jes\u00fas M. (vocal)<\/li>\n<li>Luis Castedo Exposito (vocal)<\/li>\n<li>Beatrice Quiclet-sire (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nieves Martin Laso En este trabajo se ha investigado la posible transformacion en un numero reducido de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,9740,17,416,9386],"tags":[9743,9744,9620,9742,568,9741],"class_list":["post-2276","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacos-sinteticos","category-quimica","category-quimica-organica","category-salamanca","tag-aizpurua-arbizu-jesus-m","tag-beatrice-quiclet-sire","tag-ines-sanchez-bellido","tag-josefa-anaya-mateos","tag-luis-castedo-exposito","tag-nieves-martin-laso"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=2276"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2276\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=2276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=2276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=2276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}