{"id":22766,"date":"2018-03-09T09:13:04","date_gmt":"2018-03-09T09:13:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-ciclosporina-a-sobre-la-mitocondria-del-tubulo-proximal-mecanismos-de-citotoxicidad-y-citoproteccion\/"},"modified":"2018-03-09T09:13:04","modified_gmt":"2018-03-09T09:13:04","slug":"efectos-de-ciclosporina-a-sobre-la-mitocondria-del-tubulo-proximal-mecanismos-de-citotoxicidad-y-citoproteccion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-ciclosporina-a-sobre-la-mitocondria-del-tubulo-proximal-mecanismos-de-citotoxicidad-y-citoproteccion\/","title":{"rendered":"Efectos de ciclosporina a sobre la mitocondria del t\u00fabulo proximal: mecanismos de citotoxicidad y citoprotecci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuela Castilla Barba <\/strong><\/h2>\n<p>El objetivo de este trabajo ha sido caracterizar el efecto directo de ciclosporina sobre el t\u00fabulo proximal, a fin de establecer el mecanismo lesional y su posible relaci\u00f3n con el mecanismo establecido de su acci\u00f3n inmunosupresora.  ciclosporina inhibe la proliferaci\u00f3n celular del epitelio en fase de crecimiento exponencial. Es asimismo capaz de inducir muerte celular sobre la c\u00e9lula tubular sometida a inhibici\u00f3n por contacto. Para una dosis determinada, unas c\u00e9lulas sobreviven adapt\u00e1ndose y otras entran en apoptosis. Las c\u00e9lulas adaptadas o precondicionadas son m\u00e1s resistentes a la lesi\u00f3n por cilosporina.  el mecanismo por el cual ciclosporina induce apoptosis tiene que ver con su interacci\u00f3n directa con la ciclofilina d mitocondrial impidiendo la normal formaci\u00f3n y funcionamiento del poro de transici\u00f3n mitocondrial, y la entrada de agua y fosfato a la mitocondria, con una reducci\u00f3n de la maoniog\u00e9nesis en la fosforilaci\u00f3n oxidativa y una reducci\u00f3n del control respiratorio mitocondrial.  hay ac\u00famulo progresivo de calcio libre intramitocondrial que desacopla a la respiraci\u00f3n y aumenta la producci\u00f3n de radicales libres de ox\u00edgeno y peroxinitrito, provocando una apertura tard\u00eda e irreversible de la permeabilidad mitocondrial, p\u00e9rdida de su potencial de membrana, salida de citocromo c mitocondrial. Activaci\u00f3n de caspasa 3 e inicio de la cascada apopt\u00f3tica.  hemos estudiado as\u00ed mismo el mecanismo por el que act\u00faa el \u00fanico f\u00e1rmaco descrito con potencialidad para reducir la nefrotoxicidad de ciclosporina, reduciendo su acumulaci\u00f3n en la fracci\u00f3n de membrana y en la fracci\u00f3n mitocondrial de la misma.  disminuye la inducci\u00f3n de apoptosis inducida por ciclosporina, se restaura total o parcialmente la din\u00e1mica de crecimiento epitelial y se recuperan las caracter\u00edsticas morfol\u00f3gicas y funcionales del epitelio polarizado.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de ciclosporina a sobre la mitocondria del t\u00fabulo proximal: mecanismos de citotoxicidad y citoprotecci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de ciclosporina a sobre la mitocondria del t\u00fabulo proximal: mecanismos de citotoxicidad y citoprotecci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuela Castilla Barba <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Tejedor Jorge<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafaella Pagani balletti <\/li>\n<li>pablo Mart\u00edn vasallo (vocal)<\/li>\n<li>concepci\u00f3n Guisasola zulueta (vocal)<\/li>\n<li>Luis Puente maestu (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuela Castilla Barba El objetivo de este trabajo ha sido caracterizar el efecto directo de ciclosporina sobre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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