{"id":22787,"date":"2003-05-05T00:00:00","date_gmt":"2003-05-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-oxido-na%c2%adtrico-sobre-el-receptor-del-factor-de-crecimiento-epidermico-en-celulas-normales-y-tumorales-del-sistema-nervioso-central\/"},"modified":"2003-05-05T00:00:00","modified_gmt":"2003-05-05T00:00:00","slug":"efecto-del-oxido-na%c2%adtrico-sobre-el-receptor-del-factor-de-crecimiento-epidermico-en-celulas-normales-y-tumorales-del-sistema-nervioso-central","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/efecto-del-oxido-na%c2%adtrico-sobre-el-receptor-del-factor-de-crecimiento-epidermico-en-celulas-normales-y-tumorales-del-sistema-nervioso-central\/","title":{"rendered":"Efecto del \u00f3xido n\u00edtrico sobre el receptor del factor de crecimiento epid\u00e9rmico en c\u00e9lulas normales y tumorales del sistema nervioso central"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Isabel Murillo Carretero <\/strong><\/h2>\n<p>El \u00f3xido n\u00edtrico (no) es un mensajero intercelular con m\u00faltiples funciones en el sistema nervioso. Entre ellas, se ha descrito que el no es antiproliferativo en diversos tipos celulares. En el cerebro adulto de mam\u00edferos existe formaci\u00f3n de nuevas neuronas a paritr de neuroblastos, que se encuentran principalmente en 2 zonas, hipocampo y zona subventricular (svz). No se conocen los mecanismos que regulan la neurog\u00e9nesis del cerebro adulto, pero se sabe que, en la svz, los neuroblastos aumentan su proliferaci\u00f3n en respuesta al factor de crecimiento epid\u00e9mico (egf). Resultados previos obtenidos en nuestro laboratorio mostraban que, en fibroblastos de rat\u00f3n egfr-t17 que sobreexprean en su membrana el receptor de egf (egfr) humano, el no era capaz de inhibir este receptor por un mecanismo independiente de cgmp. Por tanto, hemos establecido la hip\u00f3tesis de que en los neuroblastos de la svz, el no act\u00faa como regulador negativo de la proliferaci\u00f3n a trav\u00e9s de su interacci\u00f3n con el egfr. Para demostrarlo, hemos empleado la l\u00ednea celular de neuroblastoma humano nb69 como modelo experimental. Las c\u00e9lulas nb69, al igual que los neuroblastos de la svz, expresan beta-iii-tubulina y otras prote\u00ednas marcadoras de neuronas, y poseen en su membrana el egfr. En presencia de egf, las c\u00e9lulas nb69 aumentaron su proliferaci\u00f3n un 200% aproximadamente con respecto a c\u00e9lulas control, cultivadas en ausencia de factores de crecimiento; el mayor \u00edndice de mitosis se obtuvo con un medio de cultivo suplementado con suero al 15%. Los donantes de no snap, dea-no y deta-no inhibieron la proliferaci\u00f3n de las c\u00e9lulas nb69 de forma dependiente de la concentraci\u00f3n utilizada, y por mecanismos independientes de cgmp. No obstante, las c\u00e9lulas cultivadas en presencia de egf eran m\u00e1s sensibles al efecto citost\u00e1tico del no que aquellas cultivadas con suero o sin factores de crecimiento. al analizar, mediante western blotting, el grado de activaci\u00f3n del eg<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del \u00f3xido n\u00edtrico sobre el receptor del factor de crecimiento epid\u00e9rmico en c\u00e9lulas normales y tumorales del sistema nervioso central<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del \u00f3xido n\u00edtrico sobre el receptor del factor de crecimiento epid\u00e9rmico en c\u00e9lulas normales y tumorales del sistema nervioso central <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Isabel Murillo Carretero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Estrada Cerquera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lisardo Bosc\u00e1 gomar <\/li>\n<li>Antonio Campos caro (vocal)<\/li>\n<li> Mena g\u00f3mez m. angeles (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Esteban carretero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Isabel Murillo Carretero El \u00f3xido n\u00edtrico (no) es un mensajero intercelular con m\u00faltiples funciones en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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