{"id":22816,"date":"2003-07-05T00:00:00","date_gmt":"2003-07-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/microesferas-con-anfotericina-b-para-el-tratamiento-de-la-leishmaniosis-visceral\/"},"modified":"2003-07-05T00:00:00","modified_gmt":"2003-07-05T00:00:00","slug":"microesferas-con-anfotericina-b-para-el-tratamiento-de-la-leishmaniosis-visceral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/microesferas-con-anfotericina-b-para-el-tratamiento-de-la-leishmaniosis-visceral\/","title":{"rendered":"Microesferas con anfotericina b para el tratamiento de la leishmaniosis visceral"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  S\u00e1nchez-brunete Santos Jos\u00e9 Antonio <\/strong><\/h2>\n<p>Se describe un nuevo proceso de obtenci\u00f3n de microesferas hidrodispensables que contienen anfotericina b. Los materiales transportadores utilizados son alb\u00famina, \u00e1cido polil\u00e1ctico co-glic\u00f3lico (plga) y polianhidrido seb\u00e1cico.  el proceso de fabricaci\u00f3n se basa en la atomizaci\u00f3n del material transportador con el f\u00e1rmaco. La atomizaci\u00f3n es un proceso continuo y r\u00e1pido que se puede realizar en condiciones de asepsia, lo que permite obtener productos aptos para la administraci\u00f3n parenteral. Las microesferas obtenidas tienen un tama\u00f1o de part\u00edcula peque\u00f1o (generalmente menor de 5 micr\u00f3metros) y son hidrodispersables, por lo que se pueen administrar por v\u00eda intravenosa. de todas las formulaciones desarrolladas, las preparadas con alb\u00famina son las que han aportado mejores resultados farmacot\u00e9cnicos, farmacodin\u00e1micos y toxicol\u00f3gicos. Estudios realizados en animales de experimentaci\u00f3n han demostrado que esta nueva formulaci\u00f3n con anfotericina b es menos t\u00f3xica que fungizona(r), que es la especialidad farmac\u00e9utica con anfotericina b m\u00e1s empleada de las actualmente comercializadas, y tambi\u00e9n m\u00e1s eficaz para el tratamiento de leishmaniosis experimental en cricetos.  se realiza igualmente un estudio de la influencia del estado de agregaci\u00f3n que adoptan las mol\u00e9culas del f\u00e1rmaco, y de los excipientes y t\u00e9cnicas utilizados en la fabricaci\u00f3n.  los buenos resultados de toxicidad y de eficacia in vio obtenidos se complementan con un estudio farmacocin\u00e9tico y un estudio de estabilidad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Microesferas con anfotericina b para el tratamiento de la leishmaniosis visceral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Microesferas con anfotericina b para el tratamiento de la leishmaniosis visceral <\/li>\n<li><strong>Autor:<\/strong>\u00a0  S\u00e1nchez-brunete Santos Jos\u00e9 Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jose Torrado Duran<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Lastres garcia <\/li>\n<li>Juan  Manuel Irache garreta (vocal)<\/li>\n<li>Antonio Rabasco alvarez (vocal)<\/li>\n<li>Francisco Otero espinar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de S\u00e1nchez-brunete Santos Jos\u00e9 Antonio Se describe un nuevo proceso de obtenci\u00f3n de microesferas hidrodispensables que contienen anfotericina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[11840,67261,5847,49836,43303,67987],"class_list":["post-22816","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-antonio-rabasco-alvarez","tag-francisco-otero-espinar","tag-jose-luis-lastres-garcia","tag-juan-jose-torrado-duran","tag-juan-manuel-irache-garreta","tag-sanchez-brunete-santos-jose-antonio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22816","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22816"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22816\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22816"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22816"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22816"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}