{"id":22832,"date":"2003-08-05T00:00:00","date_gmt":"2003-08-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-aspirina-de-liberacion-sostenida-sobre-el-funcionalismo-plaquetario-en-voluntarios-sanos\/"},"modified":"2003-08-05T00:00:00","modified_gmt":"2003-08-05T00:00:00","slug":"efecto-de-aspirina-de-liberacion-sostenida-sobre-el-funcionalismo-plaquetario-en-voluntarios-sanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/efecto-de-aspirina-de-liberacion-sostenida-sobre-el-funcionalismo-plaquetario-en-voluntarios-sanos\/","title":{"rendered":"Efecto de aspirina de liberaci\u00f3n sostenida sobre el funcionalismo plaquetario en voluntarios sanos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Inmaculada Nacle L\u00f3pez <\/strong><\/h2>\n<p>La forma gal\u00e9nica de liberaci\u00f3n sostenida de \u00e1cido acetilsalic\u00edlico pretende un mejor perfil farmacocin\u00e9tica y farmacodin\u00e1mico de dicho f\u00e1rmaco, pretendiendo conseguir una liberaci\u00f3n lenta y progresiva de \u00e1cido acetilsalic\u00edlico, lo cual conlleva a la formaci\u00f3n progresiva de \u00e1cido salic\u00edlico (principal metabolito del aas). Dicho metabolito evita la inhibici\u00f3n de la s\u00edntesis de prostaciclina vascular, y por tanto, la aparici\u00f3n del principal efecto secundario derivado de la administraci\u00f3n cr\u00f3nica de aas = hemorragia gastrointestinal por inhibici\u00f3n de la s\u00edntesis de prostaciclina a nivel g\u00e1strico.  sin embargo, hasta la fecha dicha hip\u00f3tesis es s\u00f3lo te\u00f3rica, no existiendo trabajos contundentes hasta la fecha que demuestren una mejor en dicho perfil famracocin\u00e9tica y farmacodin\u00e1mico. Debido a ello, \u00e9ste ha sido el fundamento de dicho trabajo.  para ello la metodolog\u00eda seguida ha consistido en realizar estudios del funcionalismo plaquetario a trav\u00e9s de curvas agregom\u00e9tricas, mediciones de tromboxano z2, prostaciclina, \u00f3xido n\u00edtrico, nitritos y nitratos como metabolitos esenciales del funcionalismo plaquetario. Todo ello se realiz\u00f3 con sangre procedente de pacientes sanos, en un ensayos randomizado, doble ciego y cruzado, cuyo protocolo fue aprobado por el comit\u00e9 de ensayos cl\u00ednicos del hospital cl\u00ednico universitario virgen de la victoria de m\u00e1laga. As\u00ed mismo, tambi\u00e9n se realizaron estudios cin\u00e9ticos por hplc.  los resultados obtenidos en este estudio demuestran que la forma gal\u00e9nica de liberaci\u00f3n sostenida de aas ejerce un efecto antiagregante significativo y similar a la forma de liberaci\u00f3n normal, una inhibici\u00f3n de la s\u00edntesis de tromboxano a2, un respeto por la s\u00edntesis de prostaciclina en un 80%, lo cual la diferencia claramente del comportamiento de aas de liberaci\u00f3n normal, as\u00ed como un incremento en la producci\u00f3n de no, jugando a este nivel un papel importante el \u00e1cido salic\u00edlico. Estos<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de aspirina de liberaci\u00f3n sostenida sobre el funcionalismo plaquetario en voluntarios sanos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de aspirina de liberaci\u00f3n sostenida sobre el funcionalismo plaquetario en voluntarios sanos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Inmaculada Nacle L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Gonz\u00e1lez Correa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Calleja suarez <\/li>\n<li>felipe Aguado guerrero (vocal)<\/li>\n<li>julio Juan G\u00e1lvez peralta (vocal)<\/li>\n<li>david Ruiz villafranca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Inmaculada Nacle L\u00f3pez La forma gal\u00e9nica de liberaci\u00f3n sostenida de \u00e1cido acetilsalic\u00edlico pretende un mejor perfil farmacocin\u00e9tica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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