{"id":22833,"date":"2003-08-05T00:00:00","date_gmt":"2003-08-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-interaccion-in-vitro-acido-acetilsalica%c2%adlico-acido-salica%c2%adlico-sobre-el-funcionalismo-plaquetario\/"},"modified":"2003-08-05T00:00:00","modified_gmt":"2003-08-05T00:00:00","slug":"analisis-de-la-interaccion-in-vitro-acido-acetilsalica%c2%adlico-acido-salica%c2%adlico-sobre-el-funcionalismo-plaquetario","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/analisis-de-la-interaccion-in-vitro-acido-acetilsalica%c2%adlico-acido-salica%c2%adlico-sobre-el-funcionalismo-plaquetario\/","title":{"rendered":"An\u00e1lisis de la interacci\u00f3n in vitro \u00e1cido acetilsalic\u00edlico-\u00e1cido salic\u00edlico sobre el funcionalismo plaquetario"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Torres Avil\u00e9s Jos\u00e9 Antonio <\/strong><\/h2>\n<p>El estudio de la interacci\u00f3n \u00e1cido acetilsalic\u00edlico con su propio metabolito (\u00e1cido salic\u00edlico) ha permitido explicar el dilema de la dosis de este f\u00e1rmaco, partiendo a su vez el desarrollo de formas gal\u00e9nicas de liberaci\u00f3n sostenida que aprovecha esta interacci\u00f3n para mostrar un mejor perfil farmacocin\u00e9tica y farmacodin\u00e1mico.  en este trabajo se analiza la interacci\u00f3n de \u00e1cido acetilsalic\u00edlico-\u00e1cido salic\u00edlico con las principales c\u00e9lulas del torrente circulatorio: leucocitos, hemat\u00edes y plaquetas, lo cual es fundamental para el correcto entendimiento del funcionalismo plaquetario, circunstancia que hasta ahora no hab\u00eda sido analizado.  para ello la metodolog\u00eda seguida ha consistido en realizar estudios de funcionalismo plaquetario en plasma rico en plaquetas, sangre total, plasma rico en plaquetas a\u00f1adido de polimorfonucleares y plasma rico en plaquetas con leucocitos mononucleares, quedando as\u00ed analizadas todo tipo de interacci\u00f3n celular posible con ambos tipos de sustancias por separado y asociadas. por otra parte, para el an\u00e1lisis de la interacci\u00f3n leucocito-plaqueta con ambas sustancias se procedi\u00f3 a analizar un indicador de la peroxidaci\u00f3n lip\u00eddica (malondialdeh\u00eddo), ya que dicha peroxidaci\u00f3n interviene en la activaci\u00f3n plaquetaria, y se analiz\u00f3 adem\u00e1s la producci\u00f3n leucocitaria de \u00f3xido n\u00edtrico, agente inhibidor de la agregaci\u00f3n plaquetaria.  por \u00faltimo, se concluye que con dicha asociaci\u00f3n (\u00e1cido acetilsalic\u00edlico-\u00e1cido salic\u00edlico) se reduce la peroxidaci\u00f3n lip\u00eddica y se incrementa la producci\u00f3n de no leucocitario en mayor medida que cuando act\u00faan ambos por separado, increment\u00e1ndose el efecto antiagregante a trav\u00e9s de estos mecanismos bioqu\u00edmicos. tambi\u00e9n se observa que en presencia de leucocitos \u00e1cido salic\u00edlico incrementa la acci\u00f3n antiagregante de \u00e1cido acetilsalic\u00edlico.  todas estas conclusiones son aspectos novedosos que aporta este trabajo, de investigaci\u00f3n, establ<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de la interacci\u00f3n in vitro \u00e1cido acetilsalic\u00edlico-\u00e1cido salic\u00edlico sobre el funcionalismo plaquetario<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de la interacci\u00f3n in vitro \u00e1cido acetilsalic\u00edlico-\u00e1cido salic\u00edlico sobre el funcionalismo plaquetario <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Torres Avil\u00e9s Jos\u00e9 Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Pedro De La Cruz Cort\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Calleja suarez <\/li>\n<li>felipe Aguado guerrero (vocal)<\/li>\n<li>julio Juan G\u00e1lvez peralta (vocal)<\/li>\n<li>david Ruiz villafranca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Torres Avil\u00e9s Jos\u00e9 Antonio El estudio de la interacci\u00f3n \u00e1cido acetilsalic\u00edlico con su propio metabolito (\u00e1cido salic\u00edlico) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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