{"id":22837,"date":"2003-08-05T00:00:00","date_gmt":"2003-08-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-farmacocinetica-del-acido-retinoico-todo-trans-y-de-su-efecto-autoinductor\/"},"modified":"2003-08-05T00:00:00","modified_gmt":"2003-08-05T00:00:00","slug":"estudio-de-la-farmacocinetica-del-acido-retinoico-todo-trans-y-de-su-efecto-autoinductor","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-farmacocinetica-del-acido-retinoico-todo-trans-y-de-su-efecto-autoinductor\/","title":{"rendered":"Estudio de la farmacocin\u00e9tica del \u00e1cido retinoico todo trans y de su efecto autoinductor"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anas Saadeddin <\/strong><\/h2>\n<p>En la presente memoria se ha estudiado la famracocin\u00e9tica del \u00e1cido retinoico todo trans en la rata, el efecto autoinductor en su eliminaci\u00f3n y el efecto que algunas sustancias inhibidoras del citocromo p450 ejercen sobre la eliminaci\u00f3n de este f\u00e1rmaco.  el atra se ha administrado a los animales por v\u00eda intravenosa, via oral y v\u00eda subcut\u00e1nea. La determinaci\u00f3n de las concentraciones plasm\u00e1ticas de atra se ha llevado a cabo mediante un m\u00e9todo anal\u00edtico basado en la cromatograf\u00eda l\u00edquido-liquido de alta eficacia (hplc).  del trabajo realizado se pueden extraer como m\u00e1s relevantes las siguientes conclusiones:  1,- el atra presenta un comportamiento cin\u00e9tico no lineal en la rata, que se traduce en un aumento de la semivida a partir de un cierto tiempo tras su administraci\u00f3n en forma de bolus y en una disminuci\u00f3n de la concentraci\u00f3n plasm\u00e1tica cuando se administra en perfusi\u00f3n intravenosa a velocidad constante.  2,- la administraci\u00f3n del atra por v\u00eda oral y por v\u00eda subcut\u00e1nea da lugar a una baja biodisponibilidad (39% y 22%, respectivamente).  3,- la famracocin\u00e9tica no lineal del atra en la rata se ha atribuido a un efecto autoinductor de la eliminaci\u00f3n. Este efecto autoinductor se manifiesta a alrdedor de los 170 minutos posteriores a la administraci\u00f3n de una dosis \u00fanica. Como consecuencia de ello, la administraci\u00f3n de una segunda dosis da lugar a niveles plasm\u00e1ticos inferiores a los obtenidos con una dosis \u00fanica, siendo este efecto m\u00e1s acusado cuando el f\u00e1rmaco se administra por v\u00eda oral que cuando se administra por v\u00eda intravenosa.  4,- de los distintos inhibidores del citocromo p450 empleados, solo el ketoconazol manifiesta un efecto inhibidor del metabolismo del atra. No obstante, el efecto inhibidor no es lo suficientemente intenso como para inhibir la autoinducci\u00f3n de la eliminaci\u00f3n del atra.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la farmacocin\u00e9tica del \u00e1cido retinoico todo trans y de su efecto autoinductor<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la farmacocin\u00e9tica del \u00e1cido retinoico todo trans y de su efecto autoinductor <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anas Saadeddin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Esteban Peris Ribera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: marina Herraez dominguez <\/li>\n<li>Jos\u00e9 Luis Pedraz mu\u00f1oz (vocal)<\/li>\n<li> Morcillo s\u00e1nchez esteban j. (vocal)<\/li>\n<li>Antonio Rabasco alvares (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anas Saadeddin En la presente memoria se ha estudiado la famracocin\u00e9tica del \u00e1cido retinoico todo trans en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[68030,68031,11841,3308,3310,50978],"class_list":["post-22837","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-anas-saadeddin","tag-antonio-rabasco-alvares","tag-jose-esteban-peris-ribera","tag-jose-luis-pedraz-munoz","tag-marina-herraez-dominguez","tag-morcillo-sanchez-esteban-j"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22837","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22837"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22837\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22837"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22837"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22837"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}