{"id":22840,"date":"2003-08-05T00:00:00","date_gmt":"2003-08-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/deteccion-y-analisis-de-adn-fetal-en-suero-y-plasma-de-gestante-aplicacion-al-diagnostico\/"},"modified":"2003-08-05T00:00:00","modified_gmt":"2003-08-05T00:00:00","slug":"deteccion-y-analisis-de-adn-fetal-en-suero-y-plasma-de-gestante-aplicacion-al-diagnostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/deteccion-y-analisis-de-adn-fetal-en-suero-y-plasma-de-gestante-aplicacion-al-diagnostico\/","title":{"rendered":"Detecci\u00f3n y an\u00e1lisis de adn fetal en suero y plasma de gestante: aplicaci\u00f3n al diagn\u00f3stico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Gonz\u00e1lez Gonz\u00e1lez <\/strong><\/h2>\n<p>En la actualidad, para realizar un diagn\u00f3stico prenatal se realizan una serie de t\u00e9cnicas obst\u00e9tricas que conllevan un riesgo de muerte fetal de entre 0,5 y 2%. Las t\u00e9cnicas no invasivas de las que disponemos son el ec\u00f3grafo y el triple screening, sin embargo, \u00e9stas t\u00e9cnicas al no analizar directamente ning\u00fan tipo de tejido fetal no presentan una fiabilidad cercana a la que ofrece el diagn\u00f3stico prenatal invasivo. En los \u00faltimos a\u00f1os se ha intentado desarrollar un nuevo tipo de diagn\u00f3stico prenatal basado en la existencia de c\u00e9lulas fetales en el torrente sangu\u00edneo. El an\u00e1lisis de \u00e9stas c\u00e9lulas fetales presenta una tasa de detecci\u00f3n de anomal\u00edas cromos\u00f3micas cercana al 40% con un 11% de falsos positivos. Esta t\u00e9cnica presenta el inconveniente de ser excesivamente laboriosa y de alto coste, adem\u00e1s la presencia en mayor\u00eda de c\u00e9lulas maternas impide el diagn\u00f3stico de fetos hembras. La aproximaci\u00f3n m\u00e1s reciente a un nuevo tipo de diagn\u00f3stico prenatal no invasivo ha estado basada en el descubrimiento de la presencia de adn fetal en el suero y plasma de gestante. Los primeros descubrimientos sobre adn extracelular en la circulaci\u00f3n sangu\u00ednea fueron descritos por mandel y m\u00e9tais en 1948 y ya a finales de los a\u00f1os noventa el grupo de lo y cols (1997, 1998) empezaron sus investigaciones aplicadas a la detecci\u00f3n de secuencias de origen paterno en el suero y plasma de gestantes. El an\u00e1lisis de adn fetal en suero y plasma de  gestante ha permitido la detecci\u00f3n de secuencias de origen paterno como son las secuencias del cromosoma y para el diagn\u00f3stico de sexo fetal. Otros datos aportados por la bibliograf\u00eda es que el adn fetal constituye entre un 3,4 y un 6,2 del total del and presente en plasma y que su concentraci\u00f3n se ve aumentada en casos de preeclampsia y trisom\u00eda 21.  los objetivos  de esta tesis han sido la optimizaci\u00f3n de las t\u00e9cnicas de extracci\u00f3n y amplificaci\u00f3n de adn fetal en suero y plasma de ges<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Detecci\u00f3n y an\u00e1lisis de adn fetal en suero y plasma de gestante: aplicaci\u00f3n al diagn\u00f3stico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Detecci\u00f3n y an\u00e1lisis de adn fetal en suero y plasma de gestante: aplicaci\u00f3n al diagn\u00f3stico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Gonz\u00e1lez Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Ramos Corrales<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: magdalena Ugarte p\u00e9rez <\/li>\n<li>joaqu\u00edn D\u00edaz recasens (vocal)<\/li>\n<li>Santiago Rodriguez de cordoba (vocal)<\/li>\n<li>concha Hern\u00e1ndez chico (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Gonz\u00e1lez Gonz\u00e1lez En la actualidad, para realizar un diagn\u00f3stico prenatal se realizan una serie de t\u00e9cnicas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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