{"id":22873,"date":"2003-09-05T00:00:00","date_gmt":"2003-09-05T00:00:00","guid":{"rendered":""},"modified":"2003-09-05T00:00:00","modified_gmt":"2003-09-05T00:00:00","slug":"efecto-de-agentes-inductores-de-la-proliferacion-peroxisomal-sobre-la-respuesta-celular-a-esta%c2%admulos-inflamatorios-regulacion-de-la-oxido-na%c2%adtrico-sintasa-inducible-y-del-factor-de-transcri","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-agentes-inductores-de-la-proliferacion-peroxisomal-sobre-la-respuesta-celular-a-esta%c2%admulos-inflamatorios-regulacion-de-la-oxido-na%c2%adtrico-sintasa-inducible-y-del-factor-de-transcri\/","title":{"rendered":"Efecto de agentes inductores de la proliferaci\u00f3n peroxisomal sobre la respuesta celular a est\u00edmulos inflamatorios: regulaci\u00f3n de la \u00f3xido n\u00edtrico sintasa inducible y del factor de transcripci\u00f3n nf-kappab"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva M. Cernuda Moroll\u00f3n <\/strong><\/h2>\n<p>Los agentes inductores de la proliferaci\u00f3n peroxisomal, entre los que se encuentran agentes hipolipemiantes y antidiab\u00e9ticos orales, se caracterizan por su capacidad de activar a una subfamilia de receptores nucleares, los ppar. Estos f\u00e1rmacos presentan efectos beneficiosos en el tratamiento de los procesos aterog\u00e9nicos que se han relacionado con sus acciones anti-inflamatorias. se ha descrito que los agonistas de ppar inhiben la expresi\u00f3n de la forma inducible de la \u00f3xido n\u00edtrico sintasa (nosi) en distintos modelos experimentales y se ha propuesto que dicha inhibici\u00f3n es debida, al menos en parte, a la inhibici\u00f3n de la actividad transcripcional de nf-kb. Nosotros hemos observado que ciertos agonistas de ppar potencian la expresi\u00f3n de la nosi en c\u00e9lulas mesangiales activadas con est\u00edmulos inflamatorios, con la participaci\u00f3n de mecanismos de regulaci\u00f3n transcripcional. El no producido podr\u00eda contribuir a los efectos anti-inflamatorios de estos genes. Adem\u00e1s todos los agonistas empleados inhibieron la v\u00eda de activaci\u00f3n de nf-kb por distintos mecanismos. en el caso de la 15-desoxi-delta12,14 -prostaglandina j2 -prostaglandina que se produce en las c\u00e9lulas tras la inducci\u00f3n de la ciclooxigenasa-2 (cox-2)-, hemos descrito la modificaci\u00f3n covalente de la subunidad p50 de nf-kb, a trav\u00e9s de una adici\u00f3n de michael a ciste\u00edna en posici\u00f3n 62. esta modificaci\u00f3n tiene lugar en c\u00e9lulas intactas, como hemos podido demostrar mediante el empleo de una prostaglandina biotinilada. Por ello la modificaci\u00f3n postraduccional de prote\u00ednas por \u00abprostanilaci\u00f3n\u00bb podr\u00eda constituir un mecanismo de autorregulaci\u00f3n de los procesos inflamatorios.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de agentes inductores de la proliferaci\u00f3n peroxisomal sobre la respuesta celular a est\u00edmulos inflamatorios: regulaci\u00f3n de la \u00f3xido n\u00edtrico sintasa inducible y del factor de transcripci\u00f3n nf-kappab<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de agentes inductores de la proliferaci\u00f3n peroxisomal sobre la respuesta celular a est\u00edmulos inflamatorios: regulaci\u00f3n de la \u00f3xido n\u00edtrico sintasa inducible y del factor de transcripci\u00f3n nf-kappab <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva M. Cernuda Moroll\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> P\u00e9rez Sala M. Dolores<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: federico Mayor menendez <\/li>\n<li>lisardo Bosc\u00e1 gomar (vocal)<\/li>\n<li>Ana Aranda iriarte (vocal)<\/li>\n<li>Fernando Rodr\u00edguez pascual (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva M. Cernuda Moroll\u00f3n Los agentes inductores de la proliferaci\u00f3n peroxisomal, entre los que se encuentran agentes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[7262,68109,6285,68111,5664,68110],"class_list":["post-22873","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-ana-aranda-iriarte","tag-eva-m-cernuda-morollon","tag-federico-mayor-menendez","tag-fernando-rodriguez-pascual","tag-lisardo-bosca-gomar","tag-perez-sala-m-dolores"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22873","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22873"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22873\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22873"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22873"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22873"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}