{"id":2298,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/linaria-saxatilis-var-glutinosa-metabolitos-secundarios-y-analogos-bioactivos\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"linaria-saxatilis-var-glutinosa-metabolitos-secundarios-y-analogos-bioactivos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/linaria-saxatilis-var-glutinosa-metabolitos-secundarios-y-analogos-bioactivos\/","title":{"rendered":"\u00ablinaria saxatilis var. glutinosa: metabolitos secundarios y analogos bioactivos\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Puente Jimenez M. Luz De La <\/strong><\/h2>\n<p>Se ha llevado a cabo el estudio quimico-farmacologico de la especie linaria saxatilis var. Glutinosa. De los extractos descerados de la parte aerea y raices se han aislado (mediante tecnicas cromatograficas) e identificado (por sus propiedades espectroscopicas y transformaciones quimicas) 28 compuestos con esqueleto neo-clerodanico y labdanico, 13 de los cuales son nuevos productos naturales, siendo la principal diferencia entre los neo-clerodanos identificados en la parte aerea y las raices la localizacion de doble enlace del anillo biciclio (4-18, y 3 respectivamente). Por otro lado esta especie constituye el primer caso descrito de coexistencia de labdanos y clerodanos. Las transformaciones quimicas llevadas a cabo con los componentes mayoritarios generan 21 productos, 15 de los cuales no han sido descritos en bibliografia. Los ensayos de bioactividad realizados sobre un elevado numero de productos naturales y de semisintesis descritos en esta memoria han presentado en algunos casos valores de ci50 menores a   g\/m1 con indices de toxicidad muy bajos, lo que les hace merecedores de nuevos estudios.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00ablinaria saxatilis var. glutinosa: metabolitos secundarios y analogos bioactivos\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00ablinaria saxatilis var. glutinosa: metabolitos secundarios y analogos bioactivos\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Puente Jimenez M. Luz De La <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Arturo San Feliciano Martin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis San Rom\u00e1n Del Barrio <\/li>\n<li>Alejandro Fernandez Barrero (vocal)<\/li>\n<li>Enrique Ravi\u00f1a Rubira (vocal)<\/li>\n<li>Angel Gutierrez Ravelo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Puente Jimenez M. Luz De La Se ha llevado a cabo el estudio quimico-farmacologico de la especie [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,1648,17,416,9386,4204],"tags":[1887,9716,3425,2578,7196,9815],"class_list":["post-2298","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-estructura-de-moleculas-organicas","category-quimica","category-quimica-organica","category-salamanca","category-terpenos","tag-alejandro-fernandez-barrero","tag-angel-gutierrez-ravelo","tag-arturo-san-feliciano-martin","tag-enrique-ravina-rubira","tag-luis-san-roman-del-barrio","tag-puente-jimenez-m-luz-de-la"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2298","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=2298"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2298\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=2298"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=2298"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=2298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}