{"id":23004,"date":"2018-03-09T09:13:24","date_gmt":"2018-03-09T09:13:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sistemas-de-deteccion-de-traslocaciones-cromosomicas-en-leucemias-y-linfomas\/"},"modified":"2018-03-09T09:13:24","modified_gmt":"2018-03-09T09:13:24","slug":"sistemas-de-deteccion-de-traslocaciones-cromosomicas-en-leucemias-y-linfomas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/sistemas-de-deteccion-de-traslocaciones-cromosomicas-en-leucemias-y-linfomas\/","title":{"rendered":"Sistemas de detecci\u00f3n de traslocaciones cromos\u00f3micas en leucemias y linfomas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Corina Junquera S\u00e1nchez-vallejo <\/strong><\/h2>\n<p>Durante las \u00faltimas tres d\u00e9cadas cada vez ha sido mayor el n\u00famero de evidencias que han establecido una firme asociaci\u00f3n entre las anormalidades cromos\u00f3micas y determinados tipos de c\u00e1nceres humanos. La enfermedad m\u00ednima residual (emr) define a un bajo n\u00famero de c\u00e9lulas leuc\u00e9micas, que han conseguido sobrevivir a las diferentes fases del tratamiento de las que se componen los protocolos actuales, manteni\u00e9ndose por debajo de los l\u00edmites de detecci\u00f3n convencionales. Es, por tanto, fundamental la detecci\u00f3n de peque\u00f1as cantidades de estas c\u00e9lulas en el momento de la remisi\u00f3n cl\u00ednica. La detecci\u00f3n debe ser espec\u00edfica, sensible y reproducible.  se ha desarrollado un sistema de detecci\u00f3n para cada una de las traslocaciones t(14;18)y t(15;17) basado en la reacci\u00f3n en cadena de la polimerasa (pcr) y visualizaci\u00f3n en placa microtiter. Este sistema cuenta con un doble sistema de aseguramiento de la especificidad: los cebadores en la pcr y la sonda espec\u00edfica en la placa microtiter que adem\u00e1s confiere m\u00e1s sensibilidad al sistema lo que permite estudiar la emr. Debido a la falta de un m\u00e9todo de referencia entre los distintos centros de diagn\u00f3stico este m\u00e9todo, debido a sus caracter\u00edsticas de especificidad, sensibilidad y reproducibilidad puede f\u00e1cilmente aplicarse como estandar entre ellos. Adem\u00e1s es un f\u00e1cilmente automatizable en los laboratorios de diagn\u00f3stico convencionales. Para la traslocaci\u00f3n t(14;18) se ha desarrollado un sistema de semicuantificaci\u00f3n para apoyar la investigaci\u00f3n sobre los l\u00edmites de detecci\u00f3n necesarios en la emr.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sistemas de detecci\u00f3n de traslocaciones cromos\u00f3micas en leucemias y linfomas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sistemas de detecci\u00f3n de traslocaciones cromos\u00f3micas en leucemias y linfomas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Corina Junquera S\u00e1nchez-vallejo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Mart\u00ednez Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: natalia Mar\u00eda Lopez moratalia <\/li>\n<li>Miguel Pocovi mieras (vocal)<\/li>\n<li>laureano Sim\u00f3n buela (vocal)<\/li>\n<li>pilar Giraldo castellano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Corina Junquera S\u00e1nchez-vallejo Durante las \u00faltimas tres d\u00e9cadas cada vez ha sido mayor el n\u00famero de evidencias [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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