{"id":23016,"date":"2018-03-09T09:13:25","date_gmt":"2018-03-09T09:13:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-protector-de-dos-antagonistas-del-calcio-nimodipino-y-nicardipino-sobre-el-dano-tisular-intestinal-en-un-modelo-experimental-de-isquemia-mesenterica-parcial\/"},"modified":"2018-03-09T09:13:25","modified_gmt":"2018-03-09T09:13:25","slug":"efecto-protector-de-dos-antagonistas-del-calcio-nimodipino-y-nicardipino-sobre-el-dano-tisular-intestinal-en-un-modelo-experimental-de-isquemia-mesenterica-parcial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-protector-de-dos-antagonistas-del-calcio-nimodipino-y-nicardipino-sobre-el-dano-tisular-intestinal-en-un-modelo-experimental-de-isquemia-mesenterica-parcial\/","title":{"rendered":"Efecto protector de dos antagonistas del calcio, nimodipino y nicardipino, sobre el da\u00f1o tisular intestinal en un modelo experimental de isquemia mesent\u00e9rica parcial"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Tomas Palacios Jorge  De <\/strong><\/h2>\n<p>Introducci\u00f3n  la isquemia mesent\u00e9rica (im) es una situaci\u00f3n cl\u00ednica producida por un d\u00e9ficit de flujo sangu\u00edneo intestinal que puede ser mortal si no se diagnostica y trata a tiempo.  hip\u00f3tesis de trabajo y objetivos del estudio  los calcioantagonistas pueden mejorar la microcirculaci\u00f3n intestinal en sujetos con isquemia mesent\u00e9rica parcial (imp). El objetivo del estudio es obtener un modelo experimental de imp para observar el efecto del nimodipino y del nicardipino sobre el flujo mucoso intestinal y compararlo con los efectos de la dobutamina.  material y m\u00e9todos  inicialmente se estudi\u00f3 un grupo (n=4) de cerdos minipig con oclusi\u00f3n completa de la arteria mesent\u00e9rica superior (ams) durante 2-3 horas para obtener un patr\u00f3n de las alteraciones tonom\u00e9tricas y de las morfol\u00f3gicas del intestino delgado. Luego se produjo una oclusi\u00f3n parcial de la ams, permitiendo un flujo residual pr\u00f3ximo al 30%, durante 3 horas en 4 grupos de animales:  grupo 1 (control): sin administraci\u00f3n de ning\u00fan f\u00e1rmaco espec\u00edfico durante las 3 horas de imp (n=4).  grupo 2 (dobutamina): si a\u00f1adi\u00f3 una perfusi\u00f3n i.V., De dobutamina (2,5 ug\/kg\/min) durante las dos \u00faltimas horas de imp (n=4).  grupo 3 (nicardipino): se a\u00f1adi\u00f3 una perfusi\u00f3n i.V., De nicardipino (1,5-2ug\/kg\/min) durante las 2 \u00faltimas horas de imp (n=4).  grupo 4 (nimodipino): se a\u00f1adi\u00f3 una perfusi\u00f3n i.V., De nimodipino (0,6-0,8ug\/kg\/min) durante las 2 \u00faltimas horas de imp (n=4).  en todos los animales se obtuvieron muestras intestinales para estudios morfol\u00f3gicos y datos tonom\u00e9tricos mediante un ton\u00f3metro a\u00e9reo con una sonda situada en el intestino.  resultados del estudio  el nimodipino mejor\u00f3 de forma significativa (p&lt;0,05) los resultados en comparaci\u00f3n con el grupo control. La dobutamina present\u00f3 una tendencia hacia la mejora\u00eda del flujo mucoso intestinal en situaciones de imp. El grupo de animales tratados con nicardipino sufrieron un empeorami<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto protector de dos antagonistas del calcio, nimodipino y nicardipino, sobre el da\u00f1o tisular intestinal en un modelo experimental de isquemia mesent\u00e9rica parcial<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto protector de dos antagonistas del calcio, nimodipino y nicardipino, sobre el da\u00f1o tisular intestinal en un modelo experimental de isquemia mesent\u00e9rica parcial <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Tomas Palacios Jorge  De <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Turegano Fuentes Fernando J.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Balibrea  cantero <\/li>\n<li>Juan  Manuel Bell\u00f3n caneiro (vocal)<\/li>\n<li>Francisco Lozano sanchez (vocal)<\/li>\n<li>julia Buian varela (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tomas Palacios Jorge De Introducci\u00f3n la isquemia mesent\u00e9rica (im) es una situaci\u00f3n cl\u00ednica producida por un d\u00e9ficit [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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