{"id":23023,"date":"2018-03-09T09:13:25","date_gmt":"2018-03-09T09:13:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-por-la-hipertension-y-la-alta-glucosa-en-la-contractilidad-cardiaca-y-en-la-produccion-de-oxido-na%c2%adtrico-por-los-fibroblastos-cardiacos\/"},"modified":"2018-03-09T09:13:25","modified_gmt":"2018-03-09T09:13:25","slug":"alteraciones-por-la-hipertension-y-la-alta-glucosa-en-la-contractilidad-cardiaca-y-en-la-produccion-de-oxido-na%c2%adtrico-por-los-fibroblastos-cardiacos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-por-la-hipertension-y-la-alta-glucosa-en-la-contractilidad-cardiaca-y-en-la-produccion-de-oxido-na%c2%adtrico-por-los-fibroblastos-cardiacos\/","title":{"rendered":"Alteraciones por la hipertensi\u00f3n y la alta glucosa en la contractilidad cardiaca y en la producci\u00f3n de \u00f3xido n\u00edtrico por los fibroblastos cardiacos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Manso Mart\u00edn Ana M. <\/strong><\/h2>\n<p>Diabetes e hipertensi\u00f3n (hta) son dos de los principales factores de riesgo asociados a las enfermedades cardiovasculares. La hiperglucemia, definida como altas concentraciones de glucosa en sangre, es el principal factor desencadenante de las patolog\u00edas asociadas a la diabetes.  en este trabajo se estudi\u00f3 el efecto de ambos factores hta y altas concentraciones de glucosa sobre la contractilidad cardiaca en tejido ventricular de ratas espont\u00e1neamente hipertensas (shr) y su control normotenso, las ratas wistar-kyoto (wky), as\u00ed como la generaci\u00f3n de \u00f3xido n\u00edtrico (no)inducida por interleucemia 1 beta (il-1beta) en cultivos de fibroblastos cardiacos (fc) procedentes de ambas cepas de rata.  los principales resultados obtenidos en este trabajo de investigaci\u00f3n fueron los siguientes:  * el no de procedencia ex\u00f3gena ejerce un efecto modulador negativo sobre la respuesta inotr\u00f3pica positiva contr\u00e1ctil generada por isoproterenol en tiras musculares de ratas wky. Este efecto desaparece en las tiras musculares de ratas shr, en las cuales dicho no provoca un leve, aunque significativo, aumento de la contracci\u00f3n, probablemente mediado a trav\u00e9s de la generaci\u00f3n de aniones super\u00f3xido (o2).  * el no de procedencia end\u00f3gena modula negativamente la fuerza de contracci\u00f3n cardiaca generada por el isoproterenol en la cepa nomotensa, efecto que se produce a trav\u00e9s de la activaci\u00f3n de la guanilato ciclasa soluble. En la cepa hipertensa el no end\u00f3geno no altera dicha contracci\u00f3n.  * la falta de efecto modulador del no end\u00f3geno sobre la respuesta contr\u00e1ctil e isoproterenol en la cepa hipertensa no parece ser debida a cambios en la expresi\u00f3n o actividad de la \u00f3xido n\u00edtrico sintasa endotelial o de la \u00f3xido n\u00edtrico sintasa indujcible (inos) a nivel cardiaco, sino a alteraciones en el mecanismo mediador de la respuesta al no que se situar\u00eda tras la formaci\u00f3n del gmp c\u00edclico.  * la exposici\u00f3n aguda de tejido cardiaco a altas con<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones por la hipertensi\u00f3n y la alta glucosa en la contractilidad cardiaca y en la producci\u00f3n de \u00f3xido n\u00edtrico por los fibroblastos cardiacos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones por la hipertensi\u00f3n y la alta glucosa en la contractilidad cardiaca y en la producci\u00f3n de \u00f3xido n\u00edtrico por los fibroblastos cardiacos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Manso Mart\u00edn Ana M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juliana Redondo M\u00ednguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>Mar\u00eda   teresa Tejerina sanchez (vocal)<\/li>\n<li>Jes\u00fas Reviriego fern\u00e1ndez (vocal)<\/li>\n<li> Fern\u00e1ndez alfonso m. soledad (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manso Mart\u00edn Ana M. Diabetes e hipertensi\u00f3n (hta) son dos de los principales factores de riesgo asociados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[68475,68474,15297,68473,7195,4664],"class_list":["post-23023","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-fernandez-alfonso-m-soledad","tag-jesus-reviriego-fernandez","tag-juliana-redondo-minguez","tag-manso-martin-ana-m","tag-maria-teresa-tejerina-sanchez","tag-pedro-sanchez-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23023","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=23023"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23023\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=23023"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=23023"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=23023"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}