{"id":23028,"date":"2018-03-09T09:13:26","date_gmt":"2018-03-09T09:13:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-tromboticos-en-el-sindrome-antifosfolipidico-y-las-vasculitis\/"},"modified":"2018-03-09T09:13:26","modified_gmt":"2018-03-09T09:13:26","slug":"mecanismos-tromboticos-en-el-sindrome-antifosfolipidico-y-las-vasculitis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-tromboticos-en-el-sindrome-antifosfolipidico-y-las-vasculitis\/","title":{"rendered":"Mecanismos tromboticos en el sindrome antifosfolipidico y las vasculitis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gerard Espinosa Garriga <\/strong><\/h2>\n<p>Los mecanismos patog\u00e9nicos de los fen\u00f3menos tromb\u00f3ticos aparecidos en el s\u00edndrome antifosfolip\u00eddico (saf), enfermedad de beh\u00ed\u00a7et (eb) y arteritis de c\u00e9lulas gigantes (acg) no se conocen completamente. La posible implicaci\u00f3n de la fibrinolisis plasm\u00e1tica resulta muy atractiva por la importante relaci\u00f3n existente entre sus v\u00edas de activaci\u00f3n e inhibici\u00f3n y los fen\u00f3menos inflamatorios que tienen lugar en las enfermedades autoinmunes. Por otra parte, los niveles de pai-i se han relacionado con un nuevo polimorfismo de deleci\u00f3n\/inserci\u00f3n de una base (4g\/5g). Estos antecedentes nos han llevado a plantear la posible relaci\u00f3n entre este polimorfismo 4g\/5g del gen del pai-1 y las manifestaciones tromb\u00f3ticas e isqu\u00e9micas en las tres entidades analizadas. Esta relaci\u00f3n ser\u00eda secundaria a la mayor liberaci\u00f3n de pai-1 que se producir\u00eda en los pacientes con genotipo 4g\/4g, cuando la c\u00e9lula endotelial se estimula en el proceso inflamatorio. As\u00ed pues, hemos relacionado en estas tres entidades este polimorfismo y los factores de trombof\u00edlia con las manifestaciones tromb\u00f3ticas e isqu\u00e9micas.  en el primer estudio comparamos pacientes con saf, pacientes con lupus eritematoso con y sin aaf y pacientes con trombosis idiop\u00e1tica. Demostramos que no hab\u00eda diferencias en la preValencia de los factores causantes de trombof\u00edlia entre los diferentes grupos y que la presencia del alelo 4g se asoci\u00f3 significativamente al desarrollo de trombosis arteriales en el saf.  en el segundo trabajo y mediante los estudios de perfusi\u00f3n analizamos el papel que la beta2gpi juega en la interacci\u00f3n plaquetar con el subendotelio promovida por los aaf. Comparamos 3 anticuerpos anticardiolipina (acl) monoclonales anti-beta2gpi de pacientes con saf con un acl monoclonal sin actividad anti-beta2gpi, de un paciente con un linfoma son saf con un acl monoclonales aumenten la interacci\u00f3n plaquetar con el subendotelio.  en el tercer estudio comparamos los fa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos tromboticos en el sindrome antifosfolipidico y las vasculitis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos tromboticos en el sindrome antifosfolipidico y las vasculitis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gerard Espinosa Garriga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Ingelmo Mor\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>alfredo Adan civera (vocal)<\/li>\n<li> Bosch gil Jos\u00e9 angel (vocal)<\/li>\n<li>carmen Herrero mateu (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gerard Espinosa Garriga Los mecanismos patog\u00e9nicos de los fen\u00f3menos tromb\u00f3ticos aparecidos en el s\u00edndrome antifosfolip\u00eddico (saf), enfermedad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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