{"id":23035,"date":"2018-03-09T09:13:26","date_gmt":"2018-03-09T09:13:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-formacion-de-gmp-ca%c2%adclico-por-agentes-inflamatorios-en-celulas-nerviosas\/"},"modified":"2018-03-09T09:13:26","modified_gmt":"2018-03-09T09:13:26","slug":"regulacion-de-la-formacion-de-gmp-ca%c2%adclico-por-agentes-inflamatorios-en-celulas-nerviosas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-formacion-de-gmp-ca%c2%adclico-por-agentes-inflamatorios-en-celulas-nerviosas\/","title":{"rendered":"Regulaci\u00f3n de la formaci\u00f3n de gmp c\u00edclico por agentes inflamatorios en c\u00e9lulas nerviosas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pedraza Lentino Carlos Eduardo <\/strong><\/h2>\n<p>El snc se ve afectado por procesos inflamatorios en respuesta a infecciones bacterianas, a traumatismos y en los procesos relacionados con la patog\u00e9nesis de enfermedades neurodegenerativos como parkinson, alzheimer (ea), esclerosis m\u00faltiple (em) o la demencia asociada al virus de inmunodeficiencia humana (vih). La reactividad glial y expresi\u00f3n aumentada de citocinas proinflamatorias son caracter\u00edsticas comunes del proceso inflamatorio asociado a las patolog\u00edas neurodegenerativas. Las citocinas son prote\u00ednas de bajo peso molecular (entre 8 y 26 kda) que se sintetizan en casi todos los tipos celulares. se han clasificado en proinflamatorias (il-1beta, tnf-alfa, inf-gamma, ik-6) y antiinflamatorias (il-4, il-10, il-12).  las citocinas proinflamatorias, a su vez, inducen en las c\u00e9lulas del snc la expresi\u00f3n de nos-2 provocando una producci\u00f3n elevada y sostenida de no.El no es sintetizado por las \u00f3xido n\u00edtrico sintasas (nos) de las que se han descrito tres isoformas: nos-1, nos-2 y nos-3. La nos-2 se induce transcripcionalmente en respuesta a mediadores de inflamaci\u00f3n generando altas cantidades de no (nanomoles) por largos periodos de tiempo que pueden tener efectos citot\u00f3xicos. La interaccion fisiol\u00f3gica m\u00e1s importante del no es su uni\u00f3n al fe2+ del grupo hemo de la guanilil ciclasa soluble induciendo la formaci\u00f3n de gmp c\u00edclico (cgmp) a partir de gtp.  el cgmp ha sido implicado en muchas de las acciones fisiol\u00f3gicas del no, tanto en tejidos perif\u00e9ricos como el vascular. En el snc modula procesos de plasticidad sin\u00e1ptica y formaci\u00f3n de memoria, procesamiento sensorial y visual, desarrollo cerebral, secreci\u00f3n neuroendocrina y regulaci\u00f3n del flujo sangu\u00edneo cerebral. Se sabe muy poco sobre la regulaci\u00f3n de la formaci\u00f3n de cgmp dependiente de no en c\u00e9lulas del snc durante la neuroinflamaci\u00f3n.  en el presente trabajo se aportan evidencias que demuestran que agentes inflamatorios como las citocinas il-1beta y tnf-alfa,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la formaci\u00f3n de gmp c\u00edclico por agentes inflamatorios en c\u00e9lulas nerviosas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la formaci\u00f3n de gmp c\u00edclico por agentes inflamatorios en c\u00e9lulas nerviosas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pedraza Lentino Carlos Eduardo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Agustina Garc\u00eda S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: m. Hidalgo Juan <\/li>\n<li>Ana Planas (vocal)<\/li>\n<li>vicente Felipo (vocal)<\/li>\n<li>eduardo Molina-holgado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedraza Lentino Carlos Eduardo El snc se ve afectado por procesos inflamatorios en respuesta a infecciones bacterianas, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[14198,68505,68507,68504,68503,68506],"class_list":["post-23035","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-agustina-garcia-sanchez","tag-ana-planas","tag-eduardo-molina-holgado","tag-m-hidalgo-juan","tag-pedraza-lentino-carlos-eduardo","tag-vicente-felipo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23035","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=23035"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23035\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=23035"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=23035"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=23035"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}