{"id":23045,"date":"2018-03-09T09:13:27","date_gmt":"2018-03-09T09:13:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-comparativo-de-la-distribucion-pulmonar-de-antibioticos-mediante-tecnicas-de-pulmon-aislado\/"},"modified":"2018-03-09T09:13:27","modified_gmt":"2018-03-09T09:13:27","slug":"estudio-comparativo-de-la-distribucion-pulmonar-de-antibioticos-mediante-tecnicas-de-pulmon-aislado","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/estudio-comparativo-de-la-distribucion-pulmonar-de-antibioticos-mediante-tecnicas-de-pulmon-aislado\/","title":{"rendered":"Estudio comparativo de la distribuci\u00f3n pulmonar de antibi\u00f3ticos mediante t\u00e9cnicas de pulm\u00f3n aislado"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mart\u00ednez Mart\u00ednez M. Santos <\/strong><\/h2>\n<p>Se ha realizado un an\u00e1lisis comparativo de la disposici\u00f3n en tejido pulmonar de levofloxacino, cefepima y netilmicina, antibi\u00f3ticos empleados en el tratamiento de infecciones respiratorias. Dicho estudio se ha llevado a cabo utilizando t\u00e9cnicas de pulm\u00f3n aislado de rata y se ha analizado la influencia de determinados factores, particularmente el flujo tisular, sobre la cin\u00e9tica de disposici\u00f3n de los tres agentes antibacterianos.  las diferentes estrategias de an\u00e1lisis farmacocin\u00e9tico de los datos aplicadas: momentos estad\u00edsticos y modelos de dispersi\u00f3n, demuestran que los tres antibi\u00f3ticos es levofloxacino el que presenta una mayor capacidad de acceso al tejido pulmonar, siendo por lo tanto el m\u00e1s indicado, desde un punto de vista farmacocin\u00e9tico para el tratamiento de infecciones respiratorias provocadas por pat\u00f3genos intracelulares. Netilmicina y cefepima presentan un comportamiento cin\u00e9tico muy similar en tejido pulmonar.  la administraci\u00f3n simult\u00e1nea de los antibi\u00f3ticos produce una disminuci\u00f3n del grado de distribuci\u00f3n pulmonar de netilmicina y tambi\u00e9n, en menor grado, de levofloxacino y aunque las diferencias en los valores de algunos par\u00e1metros resultan ser estad\u00edsticamente significativas, la magnitud de la interacci\u00f3n detectada es moderada, pudiendo tener, o no, relevancia en el \u00e1mbito cl\u00ednico.  finalmente, se comprueba que el grado de vascularizaci\u00f3n tisular afecta significativamente a los par\u00e1metros de distribuci\u00f3n pulmonar de los tres agentes antibacterianos y aunque no se descartan otros factores, las diferencias inter-especie en el grado de vascularizaci\u00f3n tisular parecen contribuir decisivamente a las diferencias inter-especie observadas en los procesos de distribuci\u00f3n de los f\u00e1rmacos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio comparativo de la distribuci\u00f3n pulmonar de antibi\u00f3ticos mediante t\u00e9cnicas de pulm\u00f3n aislado<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio comparativo de la distribuci\u00f3n pulmonar de antibi\u00f3ticos mediante t\u00e9cnicas de pulm\u00f3n aislado <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mart\u00ednez Mart\u00ednez M. Santos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>A. S\u00e1nchez Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Dom\u00ednguel-gil <\/li>\n<li>vicente german Casabo alos (vocal)<\/li>\n<li>Mar\u00eda Jos\u00e9 Alonso fernandez (vocal)<\/li>\n<li> Garc\u00eda criado Francisco Javier (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mart\u00ednez Mart\u00ednez M. Santos Se ha realizado un an\u00e1lisis comparativo de la disposici\u00f3n en tejido pulmonar de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9386],"tags":[68529,68530,68465,52382,68528,12342],"class_list":["post-23045","post","type-post","status-publish","format-standard","hentry","category-salamanca","tag-a-sanchez-navarro","tag-alfonso-dominguel-gil","tag-garcia-criado-francisco-javier","tag-maria-jose-alonso-fernandez","tag-Martinez-Martinez-m-santos","tag-vicente-german-casabo-alos"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23045","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=23045"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23045\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=23045"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=23045"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=23045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}