{"id":23059,"date":"2018-03-09T09:13:28","date_gmt":"2018-03-09T09:13:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicaciones-cla%c2%adnicas-y-pronosticas-de-la-expresion-de-citocinas-proinflamatorias-en-la-arteritis-de-celulas-gigantes\/"},"modified":"2018-03-09T09:13:28","modified_gmt":"2018-03-09T09:13:28","slug":"implicaciones-cla%c2%adnicas-y-pronosticas-de-la-expresion-de-citocinas-proinflamatorias-en-la-arteritis-de-celulas-gigantes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicaciones-cla%c2%adnicas-y-pronosticas-de-la-expresion-de-citocinas-proinflamatorias-en-la-arteritis-de-celulas-gigantes\/","title":{"rendered":"Implicaciones cl\u00ednicas y pron\u00f3sticas de la expresi\u00f3n de citocinas proinflamatorias en la arteritis de c\u00e9lulas gigantes"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Hern\u00e1ndez Rodr\u00edguez <\/strong><\/h2>\n<p>La arteritis de c\u00e9lulas gigantes (acg) es una vasculitis granulomatosa de vasos de mediano y gran calibre que afecta con preferencia a las ramas de la arteria car\u00f3tida. Las manifestaciones craneales cl\u00e1sicas y caracter\u00edsticas de esta enfermedad, como la cefalea y la claudicaci\u00f3n mandibular, derivan de la afectaci\u00f3n inflamatoria y a veces oclusiva de las arterias del territorio carot\u00eddeo. Las m\u00e1s temidas son las que provocan la isquemia del territorio afectado por oclusi\u00f3n vascular. La m\u00e1s frecuente es la amaurosis que se produce por oclusi\u00f3n de las arterias ciliares posteriores, ramas de la arteria oft\u00e1lmica, que irrigan el nervio \u00f3ptico y producen la neuropat\u00eda \u00f3ptica isqu\u00e9mica anterior.  esta enfermedad tambi\u00e9n se caracteriza por una inflamaci\u00f3n sist\u00e9mica o de fase aguda considerable, que cl\u00ednicamente se manifiesta en forma de fiebre y p\u00e9rdida de peso en m\u00e1s de la mitad de los pacientes. La caracter\u00edstica anal\u00edtica m\u00e1s com\u00fan deriva tambi\u00e9n de esta respuesta inflamatoria sist\u00e9mica y es la elevaci\u00f3n de los reactantes de fase aguda, que junto con una anemia por bloqueo del hierro medular  comporta de forma casi invariable un aumento importante de la velocidad de sedimentaci\u00f3n globular.  las citocinas proinflamatorias (tnfalfa, il-6 e il-1beta) participan en la respuesta inflamatoria mediante la inducci\u00f3n de las manifestaciones cl\u00ednicas sist\u00e9micas y las alteraciones biol\u00f3gicas. Algunas de ellas modulan la respuesta vascular a la inflamaci\u00f3n mediante la amplificaci\u00f3n de la respuesta inflamatoria (inducci\u00f3n de la expresi\u00f3n de mol\u00e9culas de adhesi\u00f3n y quimiocinas), fen\u00f3meno que conducen a la oclusi\u00f3n vascular (hiperplasia intimal) y finalmente fen\u00f3menos reparativos del territorio da\u00f1ado y compensatorio, como la angiog\u00e9nesis, que nutre con nueva vascularizaci\u00f3n el tejido isqu\u00e9mico.  en un trabajo previo se demostr\u00f3 que la intensidad de la respuesta inflamatoria sist\u00e9mica condiciona una diferente<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaciones cl\u00ednicas y pron\u00f3sticas de la expresi\u00f3n de citocinas proinflamatorias en la arteritis de c\u00e9lulas gigantes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaciones cl\u00ednicas y pron\u00f3sticas de la expresi\u00f3n de citocinas proinflamatorias en la arteritis de c\u00e9lulas gigantes <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Hern\u00e1ndez Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Cinta Cid  Xutgl?<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Bosch gil Jos\u00e9 angel <\/li>\n<li>Antonio Vidaller palac\u00edn (vocal)<\/li>\n<li> Gonz\u00e1lez-gay mantec\u00f3n Miguel angel (vocal)<\/li>\n<li>jordi Yag\u00ed\u00bce ribes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Hern\u00e1ndez Rodr\u00edguez La arteritis de c\u00e9lulas gigantes (acg) es una vasculitis granulomatosa de vasos de mediano [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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