{"id":23070,"date":"2018-03-09T09:13:30","date_gmt":"2018-03-09T09:13:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genetica-del-sa%c2%adndrome-metabolico\/"},"modified":"2018-03-09T09:13:30","modified_gmt":"2018-03-09T09:13:30","slug":"genetica-del-sa%c2%adndrome-metabolico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genetica-del-sa%c2%adndrome-metabolico\/","title":{"rendered":"Gen\u00e9tica del s\u00edndrome metab\u00f3lico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Luis Gonz\u00e1lez S\u00e1nchez <\/strong><\/h2>\n<p>Objetivos  1,- estudiar polimorfismos en genes candidatos de componentes del s\u00edndrome metab\u00f3lico (sm) en individuos de la poblaci\u00f3n general espa\u00f1ola:  a,- polimorfismo gln27glu del gen del receptor beta2-adren\u00e9rgico.  b,- polimorfismo trp64arg del gen del receptor beta3-adren\u00e9rgico.  c,- polimorfismo -3826a-g del gen de la prote\u00edna desacoplante de la termog\u00e9nesis ucpl.  d,- polimorfismo pro12ala del gen del receptor activado por proliferadores de peroxisomas ppargamma.  e,- polimorfismo l121q del gen de la glicoprote\u00edna plasm\u00e1tica pc-1.  2,- determinar las frecuencias genot\u00edpicas de dichos polimorfismos.  3,- estudiar su asociaci\u00f3n con par\u00e1metros antropom\u00e9tricos y bioqu\u00edmicos relacionados con obesidad y otras alteraciones del sm.  4,- analizar su relaci\u00f3n con la resistencia a la insulina rl).  material y m\u00e9todos  individuos de la poblaci\u00f3n general espa\u00f1ola. Estudio i: n=666 individuos. estudio ii: n=332. Estudio iii: n=464. Estudio iv: n)293.  a.- Par\u00e1metros antropom\u00e9tricos: indice de masa corporal (imc), di\u00e1metro sagital abdominal (dsa) y cocintura cociente\/cadera (ci\/ca).  b,- presiones arteriales sist\u00f3lica y diast\u00f3lica.  c,- determinaciones biol\u00f3gicas: glucemia basal y a las 2 horas, insulina basal y a las 2 horas. Proinsulina basal y a las 2 horas. Leptina basal y a las 2 horas. Colesterol total. Colesterol-hdl y ldl y triglic\u00e9ridos. la ri se estim\u00f3 por el m\u00e9todo homa.  resultados  a,- estudio i: el polimorfismo gln27glu del receptor beta2-adren\u00e9rgico estuvo asociado con un mayor imc y dsa en varones obesos y con una mayor preValencia de diabetes mellitus tipo 2.  b,- estudio ii: el polimorfismo trp64arg del receptor beta3-adren\u00e9rgico estuvo asociado con mayores niveles de leptina, siendo los portadores de alelo arg los que presentaron incrementados los niveles de leptina despu\u00e9s de ajustar por sexo, edad, imc y ci\/ca.  c,- el polimorfismo -3826a-g est\u00e1 asociado con obesidad en las<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Gen\u00e9tica del s\u00edndrome metab\u00f3lico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Gen\u00e9tica del s\u00edndrome metab\u00f3lico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Luis Gonz\u00e1lez S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Serrano Rios<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: c\u00e9sar Nombela cano <\/li>\n<li>Ana Mar\u00eda Proenza arenas (vocal)<\/li>\n<li> Martinez larrad Mar\u00eda  teresa (vocal)<\/li>\n<li>Jos\u00e9 Luis Herrera pombo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Luis Gonz\u00e1lez S\u00e1nchez Objetivos 1,- estudiar polimorfismos en genes candidatos de componentes del s\u00edndrome metab\u00f3lico (sm) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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