{"id":23079,"date":"2018-03-09T09:13:31","date_gmt":"2018-03-09T09:13:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/correlaciones-cla%c2%adnicas-inmunopatologicas-e-inmunogeneticas-del-lupus-eritematoso-sistemico-en-la-poblacion-sevillana\/"},"modified":"2018-03-09T09:13:31","modified_gmt":"2018-03-09T09:13:31","slug":"correlaciones-cla%c2%adnicas-inmunopatologicas-e-inmunogeneticas-del-lupus-eritematoso-sistemico-en-la-poblacion-sevillana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sevilla\/correlaciones-cla%c2%adnicas-inmunopatologicas-e-inmunogeneticas-del-lupus-eritematoso-sistemico-en-la-poblacion-sevillana\/","title":{"rendered":"Correlaciones cl\u00ednicas, inmunopatol\u00f3gicas e inmunogen\u00e9ticas del lupus eritematoso sist\u00e9mico en la poblaci\u00f3n sevillana"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Nieves Respaldiza Salas <\/strong><\/h2>\n<p>El lupus eritematoso sist\u00e9mico (les) es un proceso inflamatorio considerado como el prototipo de las enfermedades autoinmunes sist\u00e9micas. Su expresi\u00f3n cl\u00ednica y biol\u00f3gica muestra una gran heterogeneidad. Las alteraciones inmunol\u00f3gicas se ponen de manifiesto por la presencia de m\u00faltiples autoanticuerpos dirigidos frente a diversas estructuras celulares. Se acepta generalmente que su etiolog\u00eda es multifactorial, con contribuciones de factores ambientales y gen\u00e9ticos.  en el presente trabajo, mediante un extenso seguimiento cl\u00ednico y biol\u00f3gico de 288 pacientes diagnosticados de les seg\u00fan los criterios revisados del colegio americano de reumatolog\u00eda (car), se ha realizado el estudio de las posibles asociaciones entre la sintomatolog\u00eda cl\u00ednica, datos biol\u00f3gicos y respueta autoinmune en el contexto de un fondo gen\u00e9tico que puede influir en la susceptibilidad a padecer la enfermedad, en la expresi\u00f3n de manifestaciones clinicas y en la producci\u00f3n de autoanticuerpos.  el estudio abarca la respuesta frente a anticuerpos convencionales del les, y hace un especial \u00e9nfasis en la detecci\u00f3n en esta patolog\u00eda de nuevos autoanticuerpos, como anticuerpos anti-dek y anticentr\u00f3metro. Se han estudiado las asociaciones cl\u00ednicas de todos estos anticuerpos con objeto de determinar posibles subgrupos dependiendo del perfil de autoanticuerpos mostrado por los pacientes. Por otro lado, se ha realizado el an\u00e1lisis de las mol\u00e9culas hla de clase ii, implicados en esta patolog\u00eda tanto en relaci\u00f3n con su distribuci\u00f3n en la susceptibilidad a padecer les como en relaci\u00f3n con su papel en la producci\u00f3n de los diferentes autoanticuerpos encontrados en esta patolog\u00eda.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Correlaciones cl\u00ednicas, inmunopatol\u00f3gicas e inmunogen\u00e9ticas del lupus eritematoso sist\u00e9mico en la poblaci\u00f3n sevillana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Correlaciones cl\u00ednicas, inmunopatol\u00f3gicas e inmunogen\u00e9ticas del lupus eritematoso sist\u00e9mico en la poblaci\u00f3n sevillana <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Nieves Respaldiza Salas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio N\u00fa\u00f1ez Rold\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  d. Bautista palomas <\/li>\n<li> Gonz\u00e1lez escribano m. francisca (vocal)<\/li>\n<li>Juan  Francisco Jimenez alonso (vocal)<\/li>\n<li>Miguel angel L\u00f3pez nevot (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Nieves Respaldiza Salas El lupus eritematoso sist\u00e9mico (les) es un proceso inflamatorio considerado como el prototipo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10715],"tags":[35286,68612,3496,2422,68611,35832],"class_list":["post-23079","post","type-post","status-publish","format-standard","hentry","category-sevilla","tag-antonio-nunez-roldan","tag-gonzalez-escribano-m-francisca","tag-juan-d-bautista-palomas","tag-juan-francisco-jimenez-alonso","tag-m-nieves-respaldiza-salas","tag-miguel-angel-lopez-nevot"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23079","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=23079"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23079\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=23079"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=23079"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=23079"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}