{"id":23114,"date":"2018-03-09T09:13:34","date_gmt":"2018-03-09T09:13:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-las-isoformas-neuronal-e-inducible-de-la-oxido-na%c2%adtrico-sintasa-y-de-la-nitracion-proteica-en-la-enfermedad-de-alzheimer\/"},"modified":"2018-03-09T09:13:34","modified_gmt":"2018-03-09T09:13:34","slug":"implicacion-de-las-isoformas-neuronal-e-inducible-de-la-oxido-na%c2%adtrico-sintasa-y-de-la-nitracion-proteica-en-la-enfermedad-de-alzheimer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/implicacion-de-las-isoformas-neuronal-e-inducible-de-la-oxido-na%c2%adtrico-sintasa-y-de-la-nitracion-proteica-en-la-enfermedad-de-alzheimer\/","title":{"rendered":"Implicaci\u00f3n de las isoformas neuronal e inducible de la \u00f3xido n\u00edtrico sintasa y de la nitraci\u00f3n prot\u00e9ica en la enfermedad de alzheimer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paula Fern\u00e1ndez-vizarra Bonet <\/strong><\/h2>\n<p>La enfermedad de alzheimer (ad) est\u00e1 caracterizada por la presencia de placas seniles (sps) y ovillos neurofibrilares (nfts) en regiones vulnerables del cerebro. La l\u00ednea principal de pensamiento actual sit\u00faa la causa primaria de la ad en la formaci\u00f3n de las sps y \u00e9stq en la secreci\u00f3n del p\u00e9ptido beta-amiloide (abeta) al medio extracelular. Sin embargo, este punto de vista est\u00e1 siendo puesto en tela de juicio por varios estudios recientes realizados con cultivos celulares y animales transg\u00e9nicos que han demostrado la existencia de dep\u00f3sitos intracelulares de abeta en neuronas. M\u00e1s recientemente, ha sido demostrada la existencia de dep\u00f3sitos intracelulares de abeta en neuronas en la corteza cerebral humana. Sin embargo, en estos estudios no se ha excluido la posibilidad de que los anticuerpos generados contra el abeta reconozcan tambi\u00e9n la prote\u00edna precursora del p\u00e9ptido beta-amiloide (app) o no se ha descrito c\u00f3mo ha sido descartada esta posibilidad.  nosotros hemos realizado un estudio inmunohistoqu\u00edmico de la formaci\u00f3n del p\u00e9ptido abeta y de los filamentos helicoidales apareados (phf) en la corteza temporal, como \u00e1rea selectivamente vulnerable en la ad, en individuos no dementes j\u00f3venes y envejecidos y en pacientes afectados por la ad espor\u00e1dica cl\u00ednicamente evaluados y clasificados de acuerdo a la escala cl\u00ednica de demencia (cdr) en el proyecto envejecimiento y memoria del centro de investigaci\u00f3n de la enfermedad de alzheimer de la universidad de washington, ee.Uu. Esta escala ha sido previamente estandarizada neuropatol\u00f3gicamente. Por otra parte, se ha demostrado que el cdr es un m\u00e9todo sensible y fiable para distinguir el evnejecimiento sin demencia de la demencia temprana de tipo ad, as\u00ed como determinar el grado de afectaci\u00f3n por la ad. Asimismo, el protocolo de evaluaci\u00f3n utilizado asegur\u00f3 que ning\u00fan individuo inlcuido en este estudio sufr\u00eda ninguna enfermedad causante de demencia distinta de la ad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n de las isoformas neuronal e inducible de la \u00f3xido n\u00edtrico sintasa y de la nitraci\u00f3n prot\u00e9ica en la enfermedad de alzheimer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n de las isoformas neuronal e inducible de la \u00f3xido n\u00edtrico sintasa y de la nitraci\u00f3n prot\u00e9ica en la enfermedad de alzheimer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paula Fern\u00e1ndez-vizarra Bonet <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Rodrigo Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Lorenzo fern\u00e1ndez <\/li>\n<li>Juan  angel Pedrosa raya (vocal)<\/li>\n<li>ricardo Mart\u00ednez murillo (vocal)<\/li>\n<li>Luis Santamar\u00eda solis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paula Fern\u00e1ndez-vizarra Bonet La enfermedad de alzheimer (ad) est\u00e1 caracterizada por la presencia de placas seniles (sps) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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