{"id":23195,"date":"2018-03-09T09:13:40","date_gmt":"2018-03-09T09:13:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/variabilidad-genetico-molecular-de-la-metabolizacion-de-xenobioticos-en-el-broncocarcinoma-primario\/"},"modified":"2018-03-09T09:13:40","modified_gmt":"2018-03-09T09:13:40","slug":"variabilidad-genetico-molecular-de-la-metabolizacion-de-xenobioticos-en-el-broncocarcinoma-primario","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/variabilidad-genetico-molecular-de-la-metabolizacion-de-xenobioticos-en-el-broncocarcinoma-primario\/","title":{"rendered":"Variabilidad gen\u00e9tico-molecular de la metabolizaci\u00f3n de xenobi\u00f3ticos en el broncocarcinoma primario"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Riveiro Cruz Manuel Alberto <\/strong><\/h2>\n<p>Las diferencias interindividuales en la capacidad metab\u00f3lica para convertir procarcin\u00f3genos en carcin\u00f3genos, o para inactivar sustancias carcin\u00f3genas, podr\u00edan tener un papel en el riesgo relativo de padecer c\u00e1ncer. Donde acontece un polimorfismo funcional, la existencia de dos o m\u00e1s fenotipos puede tner un efecto profundo en la disponibilidad, y as\u00ed en los efectos biol\u00f3gicos, de los substratos. En un n\u00famero limitado de estos casos, el substrato, o uno o m\u00e1s de sus metabolitos, es cancer\u00edgeno y, por tanto, el polimorfismo tiene el potencial de determinar, en parte, la \u00abdosis\u00bb de carcin\u00f3geno reactivo que alcanza la c\u00e9lula diana sensible, o que se forma dentro de ella. La hip\u00f3tesis que se plantea es que las diferencias interindividuales en la susceptibilidad al desarrollo de broncocarcinoma est\u00e1n determinadas, en parte, por el perfil gen\u00e9tico individual, m\u00e1s concretamente, por las variantes al\u00e9licas que expresa el individuo para los loci relacionados con el metabolismo de xenobi\u00f3ticos.  de acuerdo con esta hip\u00f3tesis, los objetivos que nos planteamos se desglosan en los siguientes t\u00e9rminos:  1,- establecer la relaci\u00f3n existente entre las variantes al\u00e9licas para cada uno de los locus considerados y el desarrollo de c\u00e1ncer de pulm\u00f3n, mediante la estima del riesgo relativo.  2,- valorar las relaciones existentes entre las diferentes combinaciones al\u00e9licas de los loci considerados y el riesgo de broncocarcinoma.  3,- investigar posibles interacciones entre uno o varios de los marcadores gen\u00e9ticos analizados y factores constitucionales (edad, sexo) o ambientales (h\u00e1bitos de tabaquismo, residencia).  el presente estudio fue dise\u00f1ado siguiendo un modelo general de casos y controles. Los individuos incluidos fueron reclutados entre 1995 y 1998 en las \u00e1reas sanitarias de a coru\u00f1a y santiago de compostela. Se incluyeron en el estudio 131 pacientes (124 hombres y 7 mujeres) diagnosticados de broncocarcinoma primario<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Variabilidad gen\u00e9tico-molecular de la metabolizaci\u00f3n de xenobi\u00f3ticos en el broncocarcinoma primario<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Variabilidad gen\u00e9tico-molecular de la metabolizaci\u00f3n de xenobi\u00f3ticos en el broncocarcinoma primario <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Riveiro Cruz Manuel Alberto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/05\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Bl\u00e1zquez Caeiro Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Rodr\u00edguez-segade villamar\u00edn <\/li>\n<li>carme Barrot feixat (vocal)<\/li>\n<li>h\u00e9ctor Verea hern\u00e1ndo (vocal)<\/li>\n<li>Mar\u00eda  de los angeles Martinez de pancorbo gomez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Riveiro Cruz Manuel Alberto Las diferencias interindividuales en la capacidad metab\u00f3lica para convertir procarcin\u00f3genos en carcin\u00f3genos, o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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