{"id":23300,"date":"2003-04-06T00:00:00","date_gmt":"2003-04-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evolucion-de-los-antioxidantes-endogenos-durante-ciruga%c2%ada-carda%c2%adaca-con-circulacion-extracorporea\/"},"modified":"2003-04-06T00:00:00","modified_gmt":"2003-04-06T00:00:00","slug":"evolucion-de-los-antioxidantes-endogenos-durante-ciruga%c2%ada-carda%c2%adaca-con-circulacion-extracorporea","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-cardiaca\/evolucion-de-los-antioxidantes-endogenos-durante-ciruga%c2%ada-carda%c2%adaca-con-circulacion-extracorporea\/","title":{"rendered":"Evoluci\u00f3n de los antioxidantes end\u00f3genos durante cirugia card\u00edaca con circulaci\u00f3n extracorp\u00f3rea"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Irene Valle Giner <\/strong><\/h2>\n<p>El objetivo principal de este trabajo es evaluar la naturaleza y magnitud de las modificaciones en los contenidos plasm\u00e1ticos de los principales antioxidantes end\u00f3genos: \u00e1cido asc\u00f3rbico, retino, alfa-tocoferol, se y gpx, durante el proceso de isquemia-reperfusi\u00f3n en cirug\u00eda a coraz\u00f3n abierto asociada a circulaci\u00f3n extracorp\u00f3rea.  para ello, previamente se han validado las t\u00e9cnicas anal\u00edticas seleccionadas para la determinaci\u00f3n de estos antioxidantes en las condiciones particulares del estudio, y se ha comprobado la estabilidad de los par\u00e1metros m\u00e1s l\u00e1biles (\u00e1cido asc\u00f3rbico, retinol, y alfa-tocoferol). Posteriormente, se han seleccionado 27 pacientes programados para cirug\u00eda de revascularizaci\u00f3n coronaria o reparaci\u00f3n o sustituci\u00f3n de v\u00e1lvulas card\u00edacas y se han toman muestras en diferentes tiempos quir\u00fargicos antes, durante la intervenci\u00f3n y una vez finalizada \u00e9sta, para caracterizar las modificaciones sufridas en las concentraciones de los distintos antioxidantes durante el procedimiento.  la t\u00e9cnica quir\u00fargica empleada implica una hemodiluci\u00f3n importante que adem\u00e1s no afecta de forma homog\u00e9nea a todos los pacientes, ni es constante durante el bypass. Para obtener la concentraci\u00f3n de los antioxidantes en las muestras, subsanando la hemodiluci\u00f3n, se ha utilizado como factor de correcci\u00f3n la hemoglobina, empleando en cada paciente y tiempo quir\u00fargico su correspondiente valor de concentraci\u00f3n.  de los resultados obtenidos se desprende que las variaciones importantes de \u00e1cido asc\u00f3rbico se presentan despu\u00e9s de la reperfusi\u00f3n, cuando ha concluido la circulaci\u00f3n extracorp\u00f3rea. La concentraci\u00f3n corregida de este antioxidante en plasma comienza a descender durante el by-pass en el tiempo quir\u00fargico 8 y representa una p\u00e9rdida del 26% (32.4 umol\/ml). Y se hace m\u00e1s patente en el noveno tiempo, con un porcentaje de p\u00e9rdida pr\u00f3ximo al 60% (18.4 umol\/ml) con respecto a los valores iniciales (43.0 umol\/ml<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evoluci\u00f3n de los antioxidantes end\u00f3genos durante cirugia card\u00edaca con circulaci\u00f3n extracorp\u00f3rea<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evoluci\u00f3n de los antioxidantes end\u00f3genos durante cirugia card\u00edaca con circulaci\u00f3n extracorp\u00f3rea <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Irene Valle Giner <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>bonmat\u00ed Mart\u00ed<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Tom\u00e1s vert <\/li>\n<li>rosaura Farre rovira (vocal)<\/li>\n<li>daniel Cardona pera (vocal)<\/li>\n<li>esteban Morcillo valverde (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Irene Valle Giner El objetivo principal de este trabajo es evaluar la naturaleza y magnitud de las 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