{"id":23385,"date":"2003-06-06T00:00:00","date_gmt":"2003-06-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-los-mecanismos-de-captacion-de-hierro-de-pasteurella-multocida\/"},"modified":"2003-06-06T00:00:00","modified_gmt":"2003-06-06T00:00:00","slug":"caracterizacion-de-los-mecanismos-de-captacion-de-hierro-de-pasteurella-multocida","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-los-mecanismos-de-captacion-de-hierro-de-pasteurella-multocida\/","title":{"rendered":"Caracterizaci\u00f3n de los mecanismos de captaci\u00f3n de hierro de pasteurella multocida"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Montserrat Bosch Gallego <\/strong><\/h2>\n<p>Los objetivos de la presente tesis doctoral han sido la caracterizaci\u00f3n de los mecanismos de captaci\u00f3n de hierro de pasteurella multocida, con el fin de contribuir al dise\u00f1o de una vacuna contra este pat\u00f3geno basada en la sobreexpresi\u00f3n de prote\u00ednas de membrana externa, receptoras de hemoglbina y\/o hemina, o en la expresi\u00f3n constitutiva de las prote\u00ednas de membrana reguladas por hierro (iromps).  se ha identificado el gen fur de p.Multocida y se ha estudiado el perfil electrofor\u00e9tico de las prote\u00ednas de membrana externa de dicho pat\u00f3geno, descubri\u00e9ndose un control de la expresi\u00f3n de una prote\u00edna mayoritariamente de membrana (omph) por parte de la prote\u00edna fur. Se ha contribuido un mutante fur y se ha demostrado que la mutaci\u00f3n de este gen no presenta ning\u00fan efecto sobre la virulencia de la cepa.  as\u00ed mismo, se ha caracterizado la regi\u00f3n cromos\u00f3mica de p.Multocida que contiene los genes exbb, exbd y tonb, detect\u00e1ndose la existencia de promotores internos en dicha regi\u00f3n y por lo tanto la expresi\u00f3n independencia de cada uno de los tres genes del sistema. Se ha estudiado la regulaci\u00f3n de la expresi\u00f3n de todos ellos, demostr\u00e1ndose que pertenecen al regul\u00f3n fu, y se han construido mutantes en los genes exbb, exbd y tonb. Se ha calculado la dosis letal 50 (dl50) de cada una de las cepas construidas, determin\u00e1ndose que cada uno de estos genes es imprescindible para el desarrollo normal de una infecci\u00f3n por p.Multocida, ya que en todos los casos se obtuvo un incremento de la dl50 superior a los tres \u00f3rdenes de magnitud con respecto la cepa salvaje.  por otro lado, se ha analizado el genoma de p.Multocida pm70 se han estudiado 9 prote\u00ednas que, por similitud con los receptores descritos en el banco de datos, podr\u00edan actuar como receptores de hemoglobina y\/o hemina. As\u00ed se ha podido determinar que algunas de ellas son capaces de unir hemoglobina y hemina (pm0040, pm0236, pm 0300, pm071, pm1081 y pm1428), mientras q<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de los mecanismos de captaci\u00f3n de hierro de pasteurella multocida<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de los mecanismos de captaci\u00f3n de hierro de pasteurella multocida <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Montserrat Bosch Gallego <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jordi Barb\u00e9 Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ruben L\u00f3pez gar\u00edca <\/li>\n<li>guillem Prats pastor (vocal)<\/li>\n<li>Mar\u00eda no Domingo \u00e1lvarez (vocal)<\/li>\n<li>Miguel Vi\u00f1as ciordia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montserrat Bosch Gallego Los objetivos de la presente tesis doctoral han sido la caracterizaci\u00f3n de los mecanismos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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