{"id":23449,"date":"2003-10-06T00:00:00","date_gmt":"2003-10-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificaciones-de-los-receptores-5-ht1a-limbicos-frontales-e-hipotalamicos-tras-el-tratamiento-analgesico-opiaceo-y-con-psicofarmacos\/"},"modified":"2003-10-06T00:00:00","modified_gmt":"2003-10-06T00:00:00","slug":"modificaciones-de-los-receptores-5-ht1a-limbicos-frontales-e-hipotalamicos-tras-el-tratamiento-analgesico-opiaceo-y-con-psicofarmacos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/modificaciones-de-los-receptores-5-ht1a-limbicos-frontales-e-hipotalamicos-tras-el-tratamiento-analgesico-opiaceo-y-con-psicofarmacos\/","title":{"rendered":"Modificaciones de los receptores 5-ht1a limbicos, frontales e hipotalamicos tras el tratamiento analgesico opiaceo y con psicofarmacos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Castro S\u00e1nchez M. Jose <\/strong><\/h2>\n<p>Dado que a nivel bibliogr\u00e1fico existen amplias referencias sobre fen\u00f3menos de sinergismo entre los receptores opi\u00e1ceos mu y serotonin\u00e9rgico 5-ht1a, nos planteamos determinar in vivo el mecanismo de acci\u00f3n implicado. Nuestros objetivos fueron determinar el efecto analg\u00e9sico, dosis dependiente y tiempo dependiente de fentanilo y su relaci\u00f3n con las caracter\u00edsticas de los receptores 5-ht1a en \u00e1reas limbicas, amigdala e hipot\u00e1lamo y comparar este efecto con el originado por los tratamientos agudo y cr\u00f3nico con imipramina, fluoxetina y same, tanto a nivel analg\u00e9sico como receptorial.  se determin\u00f3 el efecto analg\u00e9sico mediante el test de randall selitto y ante est\u00edmulo nociceptivo de tipo t\u00e9rmico y se caracterizaron los receptores 5-ht1a mediante experimento de autorradiograf\u00eda con el agonista 5-ht1a selectivo 3h-80h-dpat, entre los resultados obtenidos en este trabajo destacan que el efecto analg\u00e9sico de fentanilo agudo se asoci\u00f3 a un incremento de la densidad de los receptores 5-ht1a de \u00e1reas limbicas, amigdala e hipot\u00e1lamo. el efecto analg\u00e9sico de imipramina y same fu\u00e9 independiente de la funci\u00f3n de estos receptores, pero apareci\u00f3 en forma tiempo dependiente y tras tratamiento cr\u00f3nico igualmente se relacion\u00f3 con un incremento de la densidad de estos receptores. Fluoxetina s\u00f3lo mostr\u00f3 efecto analg\u00e9sico en tratamiento cr\u00f3nico siendo este independiente de la funci\u00f3n de los receptores 5-ht1a.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificaciones de los receptores 5-ht1a limbicos, frontales e hipotalamicos tras el tratamiento analgesico opiaceo y con psicofarmacos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificaciones de los receptores 5-ht1a limbicos, frontales e hipotalamicos tras el tratamiento analgesico opiaceo y con psicofarmacos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Castro S\u00e1nchez M. Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Inmaculada Bellido Est\u00e9vez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 aurelio Gomez luque <\/li>\n<li> Rodr\u00edguez padilla m. Luisa (vocal)<\/li>\n<li> Torres morera Luis Miguel (vocal)<\/li>\n<li> Ruiz ruiz m. isabel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Castro S\u00e1nchez M. Jose Dado que a nivel bibliogr\u00e1fico existen amplias referencias sobre fen\u00f3menos de sinergismo entre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[7834],"tags":[69513,38469,22255,69514,69515,52896],"class_list":["post-23449","post","type-post","status-publish","format-standard","hentry","category-malaga","tag-castro-sanchez-m-jose","tag-inmaculada-bellido-estevez","tag-jose-aurelio-gomez-luque","tag-rodriguez-padilla-m-luisa","tag-ruiz-ruiz-m-isabel","tag-torres-morera-luis-miguel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23449","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=23449"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23449\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=23449"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=23449"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=23449"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}