{"id":23519,"date":"2018-03-09T09:14:07","date_gmt":"2018-03-09T09:14:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-moduladores-de-la-liberacion-de-glutamato-en-corteza-cerebral-imagen-de-calcio-de-terminales-sinapticos\/"},"modified":"2018-03-09T09:14:07","modified_gmt":"2018-03-09T09:14:07","slug":"mecanismos-moduladores-de-la-liberacion-de-glutamato-en-corteza-cerebral-imagen-de-calcio-de-terminales-sinapticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-moduladores-de-la-liberacion-de-glutamato-en-corteza-cerebral-imagen-de-calcio-de-terminales-sinapticos\/","title":{"rendered":"Mecanismos moduladores de la liberaci\u00f3n de glutamato en corteza cerebral: imagen de calcio de terminales sin\u00e1pticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmelo Mill\u00e1n Ad\u00e1n <\/strong><\/h2>\n<p>Las sinapsis glutamat\u00e9rgicas constituyen el sistema de neurotransmisi\u00f3n exictatoria r\u00e1pida m\u00e1s abundante en el sistema nervioso central de los mam\u00edferos. La complejidad funcional de estas sinapsis se refleja a nivel presin\u00e1ptico en la existencia de m\u00faltiples mecanismos de control de la exocitosis, iniciados por la activaci\u00f3n de receptores que responden bien al propio glutamato (autorreceptores) o bien a otros neurotransmisores (heterorreceptores), y que potencian o inhiben la liberaci\u00f3n del neurotransmisor. en esta tesis doctoral hemos empleado una preparaci\u00f3n de terminales sin\u00e1pticos (sinaptosomas) para estudiar algunos aspectos de la modulaci\u00f3n de la neurotransmisi\u00f3n glutamat\u00e9rgica a nivel presin\u00e1ptico, centr\u00e1ndosnos principalmente en el estudio del control de la liberaci\u00f3n de glutamato por parte de autorreceptores metabotr\u00f3picos. Mediante el empleo de t\u00e9cnicas de fluorimetr\u00eda continua de glutamato hemos observado como la activaci\u00f3n de los receptores metabotr\u00f3picos del grupo iii produce una inhibici\u00f3n de la liberaci\u00f3n de glutamato a trav\u00e9s de una reducci\u00f3n en la actividad de los canales de calcio dependientes de voltaje de tipo n, por un mecanismos delimitado de membrana que depende de la activaci\u00f3n de prote\u00ednas g de tipo gi\/go. Adem\u00e1s, estos receptores reducen los niveles intracelulares de ampc en aquellas situaciones en las que existe una activaci\u00f3n previa de adenilato ciclasa, como ocurre tras la activaci\u00f3n de receptores beta-adren\u00e9rgicos, y este efecto se traduce en la supresi\u00f3n de la liberaci\u00f3n espont\u00e1nea de glutamato inducida por estos receptores.  mediante el empleo de t\u00e9cnicas de imagen de ca2+ hemos comprobado que la expresi\u00f3n de los receptores del grupo iii se encuentra restringida a una subpoblaci\u00f3n de terminales cerebrocorticales, donde inhiben la forma dr\u00e1stica la entrada de calcio en respuesta a un est\u00edmulo despolarizante, y hemos identificado inmunocitoqu\u00edmicamente los subtipos del<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos moduladores de la liberaci\u00f3n de glutamato en corteza cerebral: imagen de calcio de terminales sin\u00e1pticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos moduladores de la liberaci\u00f3n de glutamato en corteza cerebral: imagen de calcio de terminales sin\u00e1pticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmelo Mill\u00e1n Ad\u00e1n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>prieto Borja S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Ramos atance <\/li>\n<li>alfonso Araque almendros (vocal)<\/li>\n<li>Antonio Garc\u00eda Garc\u00eda (vocal)<\/li>\n<li>enrique Castro l\u00f3pez-tarruella (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmelo Mill\u00e1n Ad\u00e1n Las sinapsis glutamat\u00e9rgicas constituyen el sistema de neurotransmisi\u00f3n exictatoria r\u00e1pida m\u00e1s abundante en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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