{"id":23633,"date":"2018-03-09T09:14:16","date_gmt":"2018-03-09T09:14:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-los-esteroles-sobre-la-biosa%c2%adntesis-de-colesterol-proliferacion-y-diferenciacion-celular\/"},"modified":"2018-03-09T09:14:16","modified_gmt":"2018-03-09T09:14:16","slug":"efecto-de-los-esteroles-sobre-la-biosa%c2%adntesis-de-colesterol-proliferacion-y-diferenciacion-celular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-los-esteroles-sobre-la-biosa%c2%adntesis-de-colesterol-proliferacion-y-diferenciacion-celular\/","title":{"rendered":"Efecto de los esteroles sobre la bios\u00edntesis de colesterol, proliferaci\u00f3n y diferenciaci\u00f3n celular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Fern\u00e1ndez Hernando <\/strong><\/h2>\n<p>El colesterol, adem\u00e1s de ser precursor  de las hormonas esteroideas y de los \u00e1cidos biliares, es una mol\u00e9cula esencial para las c\u00e9lulas de mamiferos al ser uno de los principales componentes de la membrana plasm\u00e1tica, siendo necesaria en los procesos de embriog\u00e9nesis y de la proliferaci\u00f3n celular. en este \u00faltimo caso, el colesterol no se limita a ser un componente estructural sino que, como recientemente se ha demostrado en nuestro laboratorio, tambi\u00e9n ejerce un papel regulador del ciclo celular, permitiendo la transici\u00f3n de g2 a m.  continuando esta l\u00ednea experimental, en primer lugar analizamos la especificidad del colesterol en relaci\u00f3n con otros esteroles naturales (fitosteroles), en las acciones proliferativas y reguladoras del ciclo celular en c\u00e9lulas de mam\u00edfero. Para el estudio se cultivaron diferentes l\u00edneas celulares en un medio deficiente de colesterol y se trataron con un inhibidor distal de la s\u00edntesis de colesterol, como el skf 104976, analiz\u00e1ndose los efectos de los diferentes esteroles sobre la bios\u00edntesis de colesterol, la proliferaci\u00f3n y la diferenciaci\u00f3n celular.  en \u00faltimo lugar se estudio el papel del colesterol y de los derivados isoprenoides en la diferenciaci\u00f3n de c\u00e9lulas pc-12. Este modelo celular, ampliamente utilizado por otros autores, permite estudiar las conexiones entre el metabolismo del colesterol y las enfermeddades neurodegenerativas.  brevemente, hemos demostrado que los fitosteroles insaturados en la cadena lateral son potentes inhibidores competitivos de la esterol delta24 -reductasa, enzima que convierte desmosterol en colesterol. Esta acci\u00f3n podr\u00eda justificar en aprte el efecto hipocolesterol\u00e9mico de la ingesta de estos compuestos.  en cuanto a la proliferaci\u00f3n celular, en este trabajo se demuestra que la reducci\u00f3n de la disponibilidad de colesterol produce una inhibici\u00f3n de laproliferaci\u00f3n celular, acompa\u00f1ada en un retraso de la progresi\u00f3n del ciclo celular g2\/m y<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de los esteroles sobre la bios\u00edntesis de colesterol, proliferaci\u00f3n y diferenciaci\u00f3n celular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de los esteroles sobre la bios\u00edntesis de colesterol, proliferaci\u00f3n y diferenciaci\u00f3n celular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Fern\u00e1ndez Hernando <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel \u00e1ngel Lasunci\u00f3n Ripa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carmela (secretario) Cales bourdet <\/li>\n<li> Nando del jurado Francisco (vocal)<\/li>\n<li>diego Gomez coronado caceres (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Fern\u00e1ndez Hernando El colesterol, adem\u00e1s de ser precursor de las hormonas esteroideas y de los \u00e1cidos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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