{"id":23707,"date":"2018-03-09T09:14:22","date_gmt":"2018-03-09T09:14:22","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-modelo-experimental-empleado-es-util-para-valorar-la-neurotoxicidad-del-lcr-de-pacientes-con-em\/"},"modified":"2018-03-09T09:14:22","modified_gmt":"2018-03-09T09:14:22","slug":"el-modelo-experimental-empleado-es-util-para-valorar-la-neurotoxicidad-del-lcr-de-pacientes-con-em","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/el-modelo-experimental-empleado-es-util-para-valorar-la-neurotoxicidad-del-lcr-de-pacientes-con-em\/","title":{"rendered":"El modelo experimental empleado es \u00fatil para valorar la neurotoxicidad del lcr de pacientes con em"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ignacio Regidor Bailly-bailli\u00e9re <\/strong><\/h2>\n<p>1,- el modelo experimental empleado es \u00fatil para valorar la neurotoxicidad del lcr de pacientes con em.  2,- el lcr de pacientes con em contiene factores solubles que producen da\u00f1o axonal y apoptosis de neuronas en cultivo.  3- esta neurotoxicidad del lcr se relaciona con la agresividad cl\u00ednica de la enfermedad. En las formas progresivas de em, el lcr de los pacientes con mala evoluci\u00f3n, es decir, que contin\u00faan acumulando d\u00e9ficit neurol\u00f3gico, produce una disminuci\u00f3n de la viabilidad, un incremento de la apoptosis e induce da\u00f1o axonal en los cultivos de neuronas. En las formas rr de em, el lcr de los pacientes que tienen una recuperaci\u00f3n cl\u00ednica incompleta de los brotes produce tambi\u00e9n una disminuci\u00f3n de la viabilidad, un incremento de la apoptosis e induce da\u00f1o axonal en los cultivos de neuronas. Se puede concluir que hay un subgrupo de pacientes con em que tiene una forma m\u00e1s agresiva de la enfermedad.  4,- la neurotoxicidad del lcr aparece, en algunos pacientes, desde el inicio de la enfermedad.  5,- la neurotoxicidad del lcr, valorada in vitro, se relaciona con el da\u00f1o neuroaxonal de los pacientes, valorado in vivo con los m\u00e9todos indirectos (lesiones hipointensas en irm-t1).  6,- la neurona puede ser una diana primaria en la patogenia de la em. El da\u00f1o neuroaxonal en la em puede ser directo, es decir, no mediado por la desmielinizaci\u00f3n ni por las c\u00e9lulas inflamatorias o gliales. Existe un da\u00f1o neuronal primario en los pacientes con em, da\u00f1o que ser\u00eda inducido por agentes presentes en el lcr, y no un da\u00f1o neuronal secundario derivado de la degeneraci\u00f3n de la mielina.  7,- el da\u00f1o axonal parece preceder a la apoptosis in vitro.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El modelo experimental empleado es \u00fatil para valorar la neurotoxicidad del lcr de pacientes con em<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El modelo experimental empleado es \u00fatil para valorar la neurotoxicidad del lcr de pacientes con em <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ignacio Regidor Bailly-bailli\u00e9re <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Carlos \u00e1lvarez Cerme\u00f1o<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquin Ortu\u00f1o mirete <\/li>\n<li>Luisa Mar\u00eda Villar guimerans (vocal)<\/li>\n<li> Garc\u00eda merino Juan  Antonio (vocal)<\/li>\n<li>Rafael Fern\u00e1ndez mu\u00f1oz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ignacio Regidor Bailly-bailli\u00e9re 1,- el modelo experimental empleado es \u00fatil para valorar la neurotoxicidad del lcr de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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