{"id":23741,"date":"2018-03-09T09:14:25","date_gmt":"2018-03-09T09:14:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-estructurales-y-funcionales-de-la-region-terminal-de-talina\/"},"modified":"2018-03-09T09:14:25","modified_gmt":"2018-03-09T09:14:25","slug":"estudios-estructurales-y-funcionales-de-la-region-terminal-de-talina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-estructurales-y-funcionales-de-la-region-terminal-de-talina\/","title":{"rendered":"Estudios estructurales y funcionales de la regi\u00f3n terminal de talina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bego\u00f1a Garc\u00eda \u00e1lvarez <\/strong><\/h2>\n<p>La uni\u00f3n de prote\u00ednas de citoesqueleto, como la talina, a las regiones citoplasm\u00e1ticas de los principales receptores de adhesi\u00f3n a la matrizextracelular, las integrinas, media las trasducci\u00f3n bidireccional de la se\u00f1al en la membrana.  en esta tesis se presenta las estructuras a resoluci\u00f3n at\u00f3mica obtenidas por cristalograf\u00eda de rayos x de un fragmento de la cabeza de talina, sola y fusionada con varios fragmentos de la cola citopl\u00e1smatica de la integrina beta 3.  la estructura resuelta de talina es hom\u00f3loga alos subdominios f2 y f3 de los dominios ferm. Se demuestra que este fragmento de talina une y activa integrinas a trav\u00e9s de una variante nueva de la interacci\u00f3n observada entre los dominios ptb (dominios de uni\u00f3n a fosfotiroainas) y los ligandos que contienen motivos npxy.  estudios de rmn y mutag\u00e9nesis confirman los elementos cr\u00edticos de la interacci\u00f3n entre la talina y la cola citoplasm\u00e1tica de beta 3, proporcionando los paradigmas estructurales en la uni\u00f3n de integrinas al interior celular. esta interacci\u00f3n puede ser el prototipo del reconocimiento de los dominios ferm por los receptores transmembrenales. Adem\u00e1s se demuestra la exitencia de un sitio de uni\u00f3n con la f-actina en el subdominio f2 de la cabeza de talina. Esta uni\u00f3n sugiere un modo de conexi\u00f3n de integrinas a f-actina independiente del sitio de uni\u00f3n a actima en el c-terminal de talina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios estructurales y funcionales de la regi\u00f3n terminal de talina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios estructurales y funcionales de la regi\u00f3n terminal de talina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bego\u00f1a Garc\u00eda \u00e1lvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Robert Colin Liddington<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Montero carnerero <\/li>\n<li>Antonio Romero garrido (vocal)<\/li>\n<li>german Rivas caballero (vocal)<\/li>\n<li>guillermo Montoya blanco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bego\u00f1a Garc\u00eda \u00e1lvarez La uni\u00f3n de prote\u00ednas de citoesqueleto, como la talina, a las regiones citoplasm\u00e1ticas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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