{"id":23885,"date":"2018-03-09T09:14:36","date_gmt":"2018-03-09T09:14:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-valor-pronostico-y-predictivo-de-resistencia-frente-a-agentes-alquilantes-de-los-genes-mgmt-y-tp53-en-una-serie-de-astrocitomas-de-alto-grado\/"},"modified":"2018-03-09T09:14:36","modified_gmt":"2018-03-09T09:14:36","slug":"estudio-del-valor-pronostico-y-predictivo-de-resistencia-frente-a-agentes-alquilantes-de-los-genes-mgmt-y-tp53-en-una-serie-de-astrocitomas-de-alto-grado","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/estudio-del-valor-pronostico-y-predictivo-de-resistencia-frente-a-agentes-alquilantes-de-los-genes-mgmt-y-tp53-en-una-serie-de-astrocitomas-de-alto-grado\/","title":{"rendered":"Estudio del valor pron\u00f3stico y predictivo de resistencia frente a agentes alquilantes de los genes mgmt y tp53 en una serie de astrocitomas de alto grado"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esther Andi\u00f3n Ib\u00e1\u00f1ez <\/strong><\/h2>\n<p>Nuestro estudio se ha basado en los astrocitomas, la neoplasia cerebral m\u00e1s frecuente snc. En concreto se ha centrado enl os astrocitomas de alto grado, grupo donde incluyen los pacientes con menor supervivencia y mayor resistencia al tratamiento.  uno de los tratamientos que parecen resultar m\u00e1s efectivo son los agentes alquilantes donde se incluyen las nitrosureas (como el bcnu) y las tetrazinas. el mecanismo que m\u00e1s eficazmente repara dichas lesiones y por tanto responsable en gran medida de la resistencia tumoral es una enzima denominada mgmt (metilguanina-metiltransferasa). Entre sus mecanismos de inactivaci\u00f3n podemos encontrar la metilaci\u00f3n de su promotor y la regulaci\u00f3n de su expresi\u00f3n por parte del gen tp53.  hemos analizado la metilaci\u00f3n del promotor del gen mgmt mediante msp (pcr espec\u00edfica de metilaci\u00f3n), la expresi\u00f3n de su mensajero por pcr en tiempo real y de su prote\u00edna mediante inmunohistoqu\u00edmica en una serie de 50 pacientes con astrocitomas de alto grado. La metilaci\u00f3n del promotor de mgmt disminuye la transcripci\u00f3n y la traducci\u00f3n en l\u00edneas celulares, aunque no lo hemos podido demostrar en biopasias humanas por la contaminaci\u00f3n con c\u00e9lulas normales. Adem\u00e1s, es uno de los principales mecanismos de inactivaci\u00f3n de dicho gen y aumenta de manera significativa la supervivencia de pacientes con astrocitomas de alto grado tratados con agentes alquilantes.  por otro lado, las mutaciones puntuales es uno de los mecanismos de inactivaci\u00f3n del gen tp53 en astrocitomas de alto grado y no se correlaciona con la expresi\u00f3n de su prote\u00edna. Tampoco es un factor pron\u00f3stico de utilidad en la supervivencia de estos pacientes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del valor pron\u00f3stico y predictivo de resistencia frente a agentes alquilantes de los genes mgmt y tp53 en una serie de astrocitomas de alto grado<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del valor pron\u00f3stico y predictivo de resistencia frente a agentes alquilantes de los genes mgmt y tp53 en una serie de astrocitomas de alto grado <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esther Andi\u00f3n Ib\u00e1\u00f1ez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Garcia Foncillas Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: blanca Conde g\u00ed\u00bcerri <\/li>\n<li> Martinez de pancorbo Mar\u00eda  angeles (vocal)<\/li>\n<li>pedro P\u00e9rez segura (vocal)<\/li>\n<li>angel Idoate Miguel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esther Andi\u00f3n Ib\u00e1\u00f1ez Nuestro estudio se ha basado en los astrocitomas, la neoplasia cerebral m\u00e1s frecuente snc. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749],"tags":[70551,70548,70547,53895,70549,70550],"class_list":["post-23885","post","type-post","status-publish","format-standard","hentry","category-navarra","tag-angel-idoate-miguel","tag-blanca-conde-gierri","tag-esther-andion-ibanez","tag-jesus-garcia-foncillas-lopez","tag-Martinez-de-pancorbo-maria-angeles","tag-pedro-perez-segura"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23885","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=23885"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23885\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=23885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=23885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=23885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}