{"id":23940,"date":"2018-03-09T09:14:41","date_gmt":"2018-03-09T09:14:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-de-la-apoptosis-como-mecanismo-patogenico-en-el-lupus-eritematoso-sistemico\/"},"modified":"2018-03-09T09:14:41","modified_gmt":"2018-03-09T09:14:41","slug":"alteraciones-de-la-apoptosis-como-mecanismo-patogenico-en-el-lupus-eritematoso-sistemico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteraciones-de-la-apoptosis-como-mecanismo-patogenico-en-el-lupus-eritematoso-sistemico\/","title":{"rendered":"Alteraciones de la apoptosis como mecanismo patogenico en el lupus eritematoso sistemico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Miret Mas <\/strong><\/h2>\n<p>La apoptosis es un proceso de muerte celular programada que est\u00e1 involucrada en la selecci\u00f3n del repertorio de linfocitos t y en el mantenimiento de la tolerancia, ya que es el mecanismo por el que se eliminan las c\u00e9lulas que podr\u00edan dar lugar a respuestas autoinmunes.  existen evidencias de que la alteraci\u00f3n en los mecanismos apopt\u00f3ticos est\u00e1n implicados en la patogenia y la actividad de las enfermedades autoinmunes sist\u00e9micas, de las cuales, el les es la m\u00e1s representativa. Se han identificado en el ser humano algunos genes que codifican oncoprote\u00ednas y citocinas cuya transcripci\u00f3n parece ser crucial en este proceso: unos pro-apopt\u00f3ticos (fas, p53, y tnf-alfa) y otros anti-apopt\u00f3ticos (bcl-2 y il-10). Se sospecha que cambios en la expresi\u00f3n de los mismos podr\u00edan desempe\u00f1ar alg\u00fan papel en la patogenia del lupus eritematoso sist\u00e9mico, al favorecer la proliferaci\u00f3n de determinadas poblaciones celulares de efecto autorreactivo.  con los trabajos de la presente tesis doctoral nos propusimos: determinar la implicaci\u00f3n de los oncogenes (bcl-2, fas y p53) y la citocinas (il-10 y tnf-alfa) en la disregulaci\u00f3n apopt\u00f3tica que presentan los pacientes con lupus eritematoso sist\u00e9mico; estudiar la interrelaci\u00f3n existente entre ellos; y analizar la relaci\u00f3n de las posibles disregulaciones a los elementos que participan en la apoptosis con la actividad de la enfermedad l\u00fapica.  los resultados obtenidos muestran c\u00f3mo los oncogenes fas, bcl-2 y p53, las citocinas il-10 y tnf-alfa,  y la fracci\u00f3n proteica soluble del fas tienen una notable importancia en la patogenia y la actividad de la enfermedad l\u00fapica. Las v\u00edas apopt\u00f3ticas del fas y p53 son independientes entre s\u00ed. sin embargo, diversas citocinas (il-10, tnf-alfa), oncoprote\u00ednas (bcl-2) y fracciones proteicas solubles (sfas) pueden ser las encargafas de relacionarlas entre s\u00ed. La interferencia de estas v\u00edas apopt\u00f3ticas producir\u00eda una eliminaci\u00f3n deficiente de los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones de la apoptosis como mecanismo patogenico en el lupus eritematoso sistemico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones de la apoptosis como mecanismo patogenico en el lupus eritematoso sistemico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Miret Mas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Font Franco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>carmen Herrero mateu (vocal)<\/li>\n<li>vicens Fonollosa pla (vocal)<\/li>\n<li>jaume Martorell pons (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Miret Mas La apoptosis es un proceso de muerte celular programada que est\u00e1 involucrada en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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