{"id":23968,"date":"2018-03-09T09:14:43","date_gmt":"2018-03-09T09:14:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/proteccion-por-anticuerpos-monoclonales-frente-a-la-candidiasis-sistemica-experimental\/"},"modified":"2018-03-09T09:14:43","modified_gmt":"2018-03-09T09:14:43","slug":"proteccion-por-anticuerpos-monoclonales-frente-a-la-candidiasis-sistemica-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/proteccion-por-anticuerpos-monoclonales-frente-a-la-candidiasis-sistemica-experimental\/","title":{"rendered":"Protecci\u00f3n por anticuerpos monoclonales frente a la candidiasis sist\u00e9mica experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Robledo Zubiria <\/strong><\/h2>\n<p>Las infecciones por c.Albicans se han incrementado dram\u00e1ticamente durante las dos \u00faltimas d\u00e9cadas debido a una serie de factores predisponentes como la adicci\u00f3n a drogas por v\u00eda parenteral, la neutropenia, la antibioticoterapia prolongada y la inmunosupresi\u00f3n. Al aumentar la incidencia de las candidiasis, ha aumentado tambi\u00e9n la frecuencia de casos resistentes a los tratamientos hasta ahora seguros, como el fluconazol en las candidiasis superficiales. las dificultades en el tratamiento han estimulado el inter\u00e9s en otras estrategias terap\u00e9uticas como el desarrollo de vacunas preventivas, la terapia pasiva con anticuerpos o la terapia con citocinas y receptores de citocinas.  el objetivo de este trabajo ha sido el estudio de la eficacia de algunos anticuerpos monoclonales anti-c.Albicans en la protecci\u00f3n frente a la candidiasis experimental invasiva, y el estudio de los mecanismos por los que se lleva a cabo la supuesta protecci\u00f3n. Este trabajo se centra en particular en la activaci\u00f3n de los macr\u00f3fagos, dando su papel como c\u00e9lula efectora, para tratar de explicar la relaci\u00f3n entre la inmunidad celular y la humoral en las infecciones f\u00fangicas.  los resultados obtenidos en este trabajo sugieren que la protecci\u00f3n observada in vivo como consecuencia de la administraci\u00f3n del monoclonal c7, se establece en parte por la acci\u00f3n candidacida directa del anticuerpo y en parte por la activaci\u00f3n de los macr\u00f3fagos mediada por el completo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Protecci\u00f3n por anticuerpos monoclonales frente a la candidiasis sist\u00e9mica experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Protecci\u00f3n por anticuerpos monoclonales frente a la candidiasis sist\u00e9mica experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Robledo Zubiria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Jes\u00fas Sevilla Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ramon Cisterna cancer <\/li>\n<li>\u00e1ngel Dom\u00ednguez olavarri (vocal)<\/li>\n<li>federico Uruburu fern\u00e1ndez (vocal)<\/li>\n<li>pilar Ar\u00e9valo morales (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Robledo Zubiria Las infecciones por c.Albicans se han incrementado dram\u00e1ticamente durante las dos \u00faltimas d\u00e9cadas debido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12909],"tags":[9537,70736,4499,13271,39437,5148],"class_list":["post-23968","post","type-post","status-publish","format-standard","hentry","category-pais-vasco-euskal-herriko-unibertsitatea","tag-angel-dominguez-olavarri","tag-beatriz-robledo-zubiria","tag-federico-uruburu-fernandez","tag-ma-jesus-sevilla-garcia","tag-pilar-arevalo-morales","tag-ramon-cisterna-cancer"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23968","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=23968"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/23968\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=23968"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=23968"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=23968"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}