{"id":23969,"date":"2018-03-09T09:14:43","date_gmt":"2018-03-09T09:14:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genotipo-y-variantes-geneticas-en-la-region-promotora-del-gen-de-apo-e-en-la-patologa%c2%ada-cerebrovascular-aterotrombotica\/"},"modified":"2018-03-09T09:14:43","modified_gmt":"2018-03-09T09:14:43","slug":"genotipo-y-variantes-geneticas-en-la-region-promotora-del-gen-de-apo-e-en-la-patologa%c2%ada-cerebrovascular-aterotrombotica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/zaragoza\/genotipo-y-variantes-geneticas-en-la-region-promotora-del-gen-de-apo-e-en-la-patologa%c2%ada-cerebrovascular-aterotrombotica\/","title":{"rendered":"Genotipo y variantes gen\u00e9ticas en la regi\u00f3n promotora del gen de apo e en la patolog\u00eda cerebrovascular aterotromb\u00f3tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ivonne Jeric\u00f3 Pascual <\/strong><\/h2>\n<p>La aterosclerosis es una enfermedad sist\u00e9mica de naturaleza inflamatoria que afecta a arterias de mediano y gran calibre de todo el organismo. Una de sus consecuencias cl\u00ednicas es el ictus aterotromb\u00f3tico. Son m\u00faltiples los factores de riesgo de la enfermedad aterosclerosa, muchos de ellos todav\u00eda desconocidos, entre los que se encuentran los factores gen\u00e9ticos. uno de los genes m\u00e1s estudiados en este campo es el gen de la apo e. Esta apolipoprote\u00edna forma parte como prote\u00edna transportadora en vldl, quilomicrones y algunas subpoblaciones de hdl, adem\u00e1s de ser el ligando que reconocen los receptores espec\u00edficos hep\u00e1ticos para part\u00edculas remanentes (lrp).  el alelo e2 se asocia con niveles plasm\u00e1ticos de colesterol m\u00e1s bajos y el alelo e4 con niveles de colesterol m\u00e1s elevados. Existe gran cantidad de apo e en la placa ateromatosa, sintetizada a este nivel por los macr\u00f3fagos, con una funci\u00f3n antiaterog\u00e9nica al favorecer el transporte reverso de colesterol, es decir, desde la parede vascular hasta el \u00f3rgano de excreci\u00f3n (h\u00edgado).  la presencia del alelo e4 es un factor de riesgo para la enfermedad coronaria, independientemente de los niveles plasm\u00e1ticos de l\u00edpidos. Los estudios de asociaci\u00f3n con la enfermedad cerebrovascular, muestran resultados controvertidos. por otro lado, se han descrito recientemente que los polimorfismos de la regi\u00f3n promotora del gen de apo e influyen en la actividad transcripcional del gen y que el alelo -219t en el promotor es un nuevo factor de riesgo para el infarto agudo de miocardio (iam), al modular la expresi\u00f3n de apo e por el macr\u00f3fago en la lesi\u00f3n ateromatosa.  objetivo  determinar si existe alguna asociaci\u00f3n entre el genotipo de apo e y los polimorfismos &#8211; 219g\/t y -491 a\/t del promotor del gen de apo e y la patolog\u00eda cerebrovascular aterotromb\u00f3tica.  material y m\u00e9todos  muestra  150 sujetos con ictus aterotromb\u00f3tico y edad &lt;70 a\u00f1os, a los que se realiz\u00f3 extrac<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Genotipo y variantes gen\u00e9ticas en la regi\u00f3n promotora del gen de apo e en la patolog\u00eda cerebrovascular aterotromb\u00f3tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Genotipo y variantes gen\u00e9ticas en la regi\u00f3n promotora del gen de apo e en la patolog\u00eda cerebrovascular aterotromb\u00f3tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ivonne Jeric\u00f3 Pascual <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Civeira Murillo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Morales asin <\/li>\n<li>Jaime G\u00e1llego culler\u00e9 (vocal)<\/li>\n<li>lourdes Ortiz hern\u00e1ndez (vocal)<\/li>\n<li>Miguel Pocovi mieras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ivonne Jeric\u00f3 Pascual La aterosclerosis es una enfermedad sist\u00e9mica de naturaleza inflamatoria que afecta a arterias de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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