{"id":24027,"date":"2018-03-09T09:14:49","date_gmt":"2018-03-09T09:14:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/agrupacion-de-genes-de-biosa%c2%adntesis-de-acido-clavulanico-en-streptomyces-clavuligerus-analisis-de-la-region-corriente-arriba-del-gen-car\/"},"modified":"2018-03-09T09:14:49","modified_gmt":"2018-03-09T09:14:49","slug":"agrupacion-de-genes-de-biosa%c2%adntesis-de-acido-clavulanico-en-streptomyces-clavuligerus-analisis-de-la-region-corriente-arriba-del-gen-car","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/leon\/agrupacion-de-genes-de-biosa%c2%adntesis-de-acido-clavulanico-en-streptomyces-clavuligerus-analisis-de-la-region-corriente-arriba-del-gen-car\/","title":{"rendered":"Agrupaci\u00f3n de genes de bios\u00edntesis de \u00e1cido clavul\u00e1nico en streptomyces clavuligerus. an\u00e1lisis de la regi\u00f3n corriente arriba del gen car"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lorenzana Vega Luis Miguel <\/strong><\/h2>\n<p>Se han identificado 6 nuevos genes dentro de un fragmento de adn ecori-pvui de 6,5 kilobases situado corriente arriba del gen car perteneciente a la agrupaci\u00f3n de bios\u00edntesis de \u00e1cido clavul\u00e1nico.  los dos primeros genes han sido denominados cyp y fd respectivamente, dada la alta similitud de las prote\u00ednas deducidas con este tipo de prote\u00ednas de otros organismos. Ambas prote\u00ednas forman una unidad funcional junto con una nadph-ferredoxina oxidorreductasa, cuyo gen no esta presente dentro del fragmento ecori-pvui, y que en conjunto forman el sistema citocromo p450 hidroxilasa. La interrupci\u00f3n del gen cyp provoca la p\u00e9rdida de la capacidad de bios\u00edntesis de \u00e1cido clavul\u00e1nico, sin embargo no se ha podido determinar el punto de actuaci\u00f3n de este sistema dentro de la ruta biosint\u00e9tica de \u00e1cido clavul\u00e1nico.  el tercer gen, denominado orf-12 codifica una prote\u00edna que presenta similitud con la prote\u00edna lpqf de mycobacterium tuberculosis, de funci\u00f3n desconocida. La inactivaci\u00f3n de este gen afecta negativamente a la producci\u00f3n de \u00e1cido clavul\u00e1nico.  la prote\u00edna deducida del cuarto gen, orf-13, muestra similitud con permeasas de membrana, y aunque no se ha determinado su papel dentro de la bios\u00edntesis de \u00e1cido clavul\u00e1nico, podr\u00eda estar implicado en el transporte de intermediarios de la bios\u00edntesis de \u00e1cido clavul\u00e1nico.  el quinto gen, orf-14, cuya prote\u00edna deducida muestra homolog\u00eda con acetiltransferasas. La inactivaci\u00f3n de este gen mediante interrupci\u00f3n g\u00e9nica afecta a la producci\u00f3n de \u00e1cido clavul\u00e1nico, quedando esta disminu\u00edda a un 25% de la producci\u00f3n de la cepa silvestre.  el \u00faltimo gen, orf-15, codifica una prote\u00edna que muestra similitud con prote\u00ednas extracelulares que unen oligop\u00e9ptidos. En streptomyces coelicolor este tipo de prote\u00edna esta encargada de captar oligop\u00e9ptidos se\u00f1al que controlan procesos como la esporulaci\u00f3n y la producci\u00f3n de antibi\u00f3ticos. la prote\u00edna deducida de orf-15<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Agrupaci\u00f3n de genes de bios\u00edntesis de \u00e1cido clavul\u00e1nico en streptomyces clavuligerus. an\u00e1lisis de la regi\u00f3n corriente arriba del gen car<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Agrupaci\u00f3n de genes de bios\u00edntesis de \u00e1cido clavul\u00e1nico en streptomyces clavuligerus. an\u00e1lisis de la regi\u00f3n corriente arriba del gen car <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lorenzana Vega Luis Miguel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Paloma Liras Pad\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Francisco Mart\u00edn mart\u00edn <\/li>\n<li>encarnaci\u00f3n Mellado dur\u00e1n (vocal)<\/li>\n<li>alfredo Fern\u00e1ndez bra\u00f1a (vocal)<\/li>\n<li>Antonio Jimenez-Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lorenzana Vega Luis Miguel Se han identificado 6 nuevos genes dentro de un fragmento de adn ecori-pvui [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[4430],"tags":[25586,9593,26642,4494,70868,4496],"class_list":["post-24027","post","type-post","status-publish","format-standard","hentry","category-leon","tag-alfredo-fernandez-brana","tag-antonio-jimenez-Martinez","tag-encarnacion-mellado-duran","tag-juan-francisco-martin-martin","tag-lorenzana-vega-luis-miguel","tag-paloma-liras-padin"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24027","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24027"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24027\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24027"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24027"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}