{"id":24116,"date":"2018-03-09T09:14:56","date_gmt":"2018-03-09T09:14:56","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/variabilidad-genetica-de-las-regiones-ns5a-y-el-del-virus-de-la-hepatitis-c-y-respuesta-al-tratamiento-antivirico\/"},"modified":"2018-03-09T09:14:56","modified_gmt":"2018-03-09T09:14:56","slug":"variabilidad-genetica-de-las-regiones-ns5a-y-el-del-virus-de-la-hepatitis-c-y-respuesta-al-tratamiento-antivirico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/variabilidad-genetica-de-las-regiones-ns5a-y-el-del-virus-de-la-hepatitis-c-y-respuesta-al-tratamiento-antivirico\/","title":{"rendered":"Variabilidad gen\u00e9tica de las regiones ns5a y el del virus de la hepatitis c  y respuesta al tratamiento antivirico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francesc Puig-basagoiti <\/strong><\/h2>\n<p>Hasta el momento varias regiones de la prote\u00edna ns5a y el del virus han sido relacionadas con la respuesta al tratamiento antiv\u00edrico en funci\u00f3n a su variabilidad gen\u00e9tica y al n\u00famero de mutaciones presentes en ella. adem\u00e1s, en estas regiones (pkr-bd, isdr, v3 y pephb) la estructura y evoluci\u00f3n de las quasiespecies podr\u00eda tener un papel importante para determinar el tipo de respuesta al tratamiento antiv\u00edrico.  en la presente tesis se analizan dichas regiones en un amplio grupo de pacientes infectados con genotipo ib y tratados con ifn o con ifn+ribovirina. el n\u00famero de mutaciones en isbr, pkr-bd y v3 parece estar relacionado con el tipo de respuesta siendo estas m\u00e1s numerosas en las secuencias de los &#8212; pacientes respondedores que en las de los no respondedores.  tanto la estructura como la evoluci\u00f3n de las quasiespecies es diferente entre el grupo de respondedores y no respondedores siendo estas diferencias mucho mayores en la regi\u00f3n v3 que en el resto de las regiones analizadas en la ns5a.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Variabilidad gen\u00e9tica de las regiones ns5a y el del virus de la hepatitis c  y respuesta al tratamiento antivirico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Variabilidad gen\u00e9tica de las regiones ns5a y el del virus de la hepatitis c  y respuesta al tratamiento antivirico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francesc Puig-basagoiti <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Carlos S\u00e1iz Calahorra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Villaverde corrales <\/li>\n<li>Miguel Bruguera cortada (vocal)<\/li>\n<li>ramon Planas vila (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francesc Puig-basagoiti Hasta el momento varias regiones de la prote\u00edna ns5a y el del virus han sido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,35,280],"tags":[14154,71080,36638,13802,1156],"class_list":["post-24116","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-de-la-vida","category-virologia","tag-antonio-villaverde-corrales","tag-francesc-puig-basagoiti","tag-juan-carlos-saiz-calahorra","tag-miguel-bruguera-cortada","tag-ramon-planas-vila"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24116","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24116"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24116\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24116"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24116"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}