{"id":24135,"date":"2018-03-09T09:14:57","date_gmt":"2018-03-09T09:14:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-condicionantes-de-la-viabilidad-del-injerto-en-el-trasplante-hepatico-humano\/"},"modified":"2018-03-09T09:14:57","modified_gmt":"2018-03-09T09:14:57","slug":"factores-condicionantes-de-la-viabilidad-del-injerto-en-el-trasplante-hepatico-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-condicionantes-de-la-viabilidad-del-injerto-en-el-trasplante-hepatico-humano\/","title":{"rendered":"Factores condicionantes de la viabilidad del injerto en el trasplante hep\u00e1tico humano"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Olmedilla Arnal Luis Enrique <\/strong><\/h2>\n<p>El trasplante hep\u00e1tico humano (th) es una opci\u00f3n terap\u00e9utica habitual para los pacientes con enfermedades hep\u00e1ticas avanzadas. Sin embargo todav\u00eda se produce una considerable morbi-mortalidad en relaci\u00f3n con complicaciones como la hipotensi\u00f3n tras la reperfusi\u00f3n (s\u00edndrome de reperfusi\u00f3n -spr-) y especialmente con la lesi\u00f3n de isquemia-reperfusi\u00f3n del injerto (i-r). estas dos situciones podr\u00edan estar relacionadas con alteraciones de la s\u00edntesis del \u00f3xido n\u00edtrico (no) en el injerto.  el objetivo de este trabajo es investigar 1\u00c2\u00ba si se producen estas alteraciones de la s\u00edntesis del no en el injerto, 2\u00c2\u00ba identificar las sustancias que originen estas alteraciones y 3\u00c2\u00ba analizar la posible relaci\u00f3n entre las alteraciones de la s\u00edntesis del no y la incidencia de spr y la funci\u00f3n precoz del injerto.  en ninguna biopsia del injerto hemos encontrado una expresi\u00f3n de la inos por an\u00e1lisis northern ni western blot. En el inicio de la reperfusi\u00f3n, el lavado del injerto inhibe reversiblemente la actividad tanto de la enos (disminuye la relajaci\u00f3n inducida por acetilcolina en anillos de aorta de conejo pre-contra\u00eddos con noradrenalina) como de la inos (disminuye la formaci\u00f3n de nitritos\/nitratos y de citrulina marcada a partir de arginina 14c, en cultivos de macr\u00f3fagos de rat\u00f3n activados con lipopolisac\u00e1rido bacteriano).  hemos identificado la presencia de l-n-monometil-arginina y dimetil-arginina asim\u00e9trica en el lavado del injerto como los dos principales inhibidores de la nos, por hplc y espectrometr\u00eda de masas. Dichos inhibidores se producen y se acumulan en el injerto durante la isquemia. El spr no se produce por liberaci\u00f3n de no desde el injerto. Encontramos una asociaci\u00f3n entre la presencia de metilargininas inhibidores en el lavado del injerto y la incidencia de spr, pero sin relaci\u00f3n causa-efecto. Existe una relaci\u00f3n estad\u00edstica entre la concentraci\u00f3n de metilargininas y la funci\u00f3n precoz del injerto, con<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores condicionantes de la viabilidad del injerto en el trasplante hep\u00e1tico humano<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores condicionantes de la viabilidad del injerto en el trasplante hep\u00e1tico humano <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Olmedilla Arnal Luis Enrique <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/06\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Paloma Martin Sanz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 angel Fuentes cubero <\/li>\n<li>ramon Bartrons bach (vocal)<\/li>\n<li>joan Rosell\u00f3 catafan (vocal)<\/li>\n<li>Mar\u00eda no S\u00e1nchez crespo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Olmedilla Arnal Luis Enrique El trasplante hep\u00e1tico humano (th) es una opci\u00f3n terap\u00e9utica habitual para los pacientes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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