{"id":24205,"date":"2003-01-07T00:00:00","date_gmt":"2003-01-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-molecular-de-genes-implicados-en-la-biosintesis-de-antibioticos-macrolidos-por-streptomyces-sp\/"},"modified":"2003-01-07T00:00:00","modified_gmt":"2003-01-07T00:00:00","slug":"caracterizacion-molecular-de-genes-implicados-en-la-biosintesis-de-antibioticos-macrolidos-por-streptomyces-sp","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/caracterizacion-molecular-de-genes-implicados-en-la-biosintesis-de-antibioticos-macrolidos-por-streptomyces-sp\/","title":{"rendered":"Caracterizacion molecular de genes implicados en la biosintesis de antibioticos macrolidos por streptomyces sp."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Seco Martin Elena M. <\/strong><\/h2>\n<p>Se ha  llevado a cabo una caracterizaci\u00f3n de los metabolitos activos producidos por streptomyces sp. 108, una cepa aislada de suelos, revelando la presencia de oxitetraciclina (bactericida) y dos antibi\u00f3ticos macr\u00f3lidos tetraenos (fungicidas) en el caldo de cultivo. Se ha caracterizado parcialmente el \u00abcluster\u00bb biosint\u00e9tico de ambos tetraenos, revelando la presencia de genes que parecen intervenir claramente en la formaci\u00f3n de uno u otro  compuesto. adem\u00e1s, se muestra la caracterizaci\u00f3n parcial de otro \u00abcluster\u00bb de bios\u00edntesis de un probable macr\u00f3lido no polieno sin identificar. Disrupci\u00f3n en las diferentes rutas biosint\u00e9ticas han puesto de manifiesto competencias metab\u00f3licas entre ellas.  mediante manipulaci\u00f3n gen\u00e9tica de alguno de los genes del \u00abcluster\u00bb biosint\u00e9tico de los tetraenos se ha favorecido la producci\u00f3n de nuevos macr\u00f3lidos tetraenos, algunos de ellos con mayor actividad biol\u00f3gica y mayor solubilidad que los parentales 108i y 108ii, cuya modificaci\u00f3n qu\u00edmica ser\u00eda interesante extrapolar a otros tetraenos de inter\u00e9s industrial.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion molecular de genes implicados en la biosintesis de antibioticos macrolidos por streptomyces sp.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion molecular de genes implicados en la biosintesis de antibioticos macrolidos por streptomyces sp. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Seco Martin Elena M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Malpartida Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Salas fernandez <\/li>\n<li>Miguel Fernandez moreno (vocal)<\/li>\n<li>ram\u00f3n Santamar\u00eda s\u00e1nchez (vocal)<\/li>\n<li>Antonio Jimenez-Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Seco Martin Elena M. Se ha llevado a cabo una caracterizaci\u00f3n de los metabolitos activos producidos por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426],"tags":[9593,9322,9320,14990,9093,71281],"class_list":["post-24205","post","type-post","status-publish","format-standard","hentry","category-alcala","tag-antonio-jimenez-Martinez","tag-francisco-malpartida-romero","tag-jose-antonio-salas-fernandez","tag-miguel-fernandez-moreno","tag-ramon-santamaria-sanchez","tag-seco-martin-elena-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24205","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24205"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24205\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24205"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24205"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24205"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}