{"id":24224,"date":"2003-02-07T00:00:00","date_gmt":"2003-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-dominio-pres-en-el-proceso-infectivo-del-virus-de-la-hepatitis-b\/"},"modified":"2003-02-07T00:00:00","modified_gmt":"2003-02-07T00:00:00","slug":"implicacion-del-dominio-pres-en-el-proceso-infectivo-del-virus-de-la-hepatitis-b","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-dominio-pres-en-el-proceso-infectivo-del-virus-de-la-hepatitis-b\/","title":{"rendered":"Implicaci\u00f3n del dominio pres en el proceso infectivo del virus de la hepatitis b"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Delgado Chavero Carmen Luz <\/strong><\/h2>\n<p>Los dominios pres aislados del virus de la hepatitis b son capaces de interaccionar con ves\u00edculas de fosfol\u00edpidos \u00e1cidos, teniendo lugar un cambio conformacional en la prote\u00edna como consecuencia de dichas interacci\u00f3n. el objetivo del presente trabajo es determinar la posible implicaci\u00f3n de las diferentes zonas del dominio pres1 en las primeras etapas del ciclo infectivo del hbv.  para ello, se han obtenido cinco prote\u00ednas mutantes del dominio pres1 del hbv, en las que se han eliminado 40 amino\u00e1cidos a lo largo de la secuencia, y se han caracterizado espectrosc\u00f3picamente mediante fluorescencia y dicro\u00edsmo circular, comprobando que en todos los casos mantienen la estructura poco ordenada y con alto porcentaje en estructura beta t\u00edpica de la prote\u00edna completa. Todas estas prote\u00ednas son capaces de insertarse en el interior de la matriz lip\u00eddica de ves\u00edculas de dmpg. Adem\u00e1s, se ha estudiado la interacci\u00f3n de las prote\u00ednas con ves\u00edculas de fosfol\u00edpidos \u00e1cidos, pg, y se ha visto que producen, en mayor o menor medida, los efectos de agregaci\u00f3n y desestabilizaci\u00f3n de ves\u00edculas observadas con el dominio pres1.  adem\u00e1s, se ha obtenido el dominio pres del dhbv con una extensi\u00f3n de 6 residuos de histidina en su extremo carboxilo-terminal. El m\u00e9todo empleado permite la purificaci\u00f3n de 15-20 mg de prote\u00edna\/l de cultivo con un alto grado de pureza. Se ha caracterizado la prote\u00edna mediante t\u00e9cnicas espectrosc\u00f3picas y se ha estudiado su interacci\u00f3n con ves\u00edculas de fosfol\u00edpidos, comprobando que tanto su estructura como un comportamiento es similar al descrito para el dominio pres del hbv, a pesar de la escasa homolog\u00eda de secuencia, lo que pone de manifiesto la implicaci\u00f3n de esta regi\u00f3n en las etapas iniciales del ciclo infectivo de los hepadnavirus. Se ha obtenido el dominio pres del dhbv miristoilado.  el m\u00e9todo de purificaci\u00f3n empleado permite obtener 6 mg de prote\u00edna\/l de cultivo con un alto grado de pureza,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n del dominio pres en el proceso infectivo del virus de la hepatitis b<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n del dominio pres en el proceso infectivo del virus de la hepatitis b <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Delgado Chavero Carmen Luz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Gavilanes Franco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  antonia Lizarbe  iracheta <\/li>\n<li>Luis Menendez arias (vocal)<\/li>\n<li>Jos\u00e9 Manuel Gonzalez ros (vocal)<\/li>\n<li>Mar\u00eda Gasset vega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Delgado Chavero Carmen Luz Los dominios pres aislados del virus de la hepatitis b son capaces de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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