{"id":24227,"date":"2003-02-07T00:00:00","date_gmt":"2003-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-hipotiroidismo-sobre-la-plasticidad-sinaptica-en-el-hipocampo-de-rata\/"},"modified":"2003-02-07T00:00:00","modified_gmt":"2003-02-07T00:00:00","slug":"efectos-del-hipotiroidismo-sobre-la-plasticidad-sinaptica-en-el-hipocampo-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-hipotiroidismo-sobre-la-plasticidad-sinaptica-en-el-hipocampo-de-rata\/","title":{"rendered":"Efectos del hipotiroidismo sobre la plasticidad sin\u00e1ptica en el hipocampo de rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Hugo Vara Rivera <\/strong><\/h2>\n<p>La deficiencia de hormona tiroidea (t3) durante un per\u00edodo cr\u00edtico del desarrollo afecta profundamente a funciones cognitivas tales como atenci\u00f3n, aprendizaje y memoria. Se piensa que la plasticidad sin\u00e1ptica a largo plazo es esencial para el aprendizaje y la memoria y para la regulaci\u00f3n actividad-dependiente de la formaci\u00f3n de sinapsis durante el desarrollo del cerebro. Tambi\u00e9n la modificaci\u00f3n a corto plazo de la eficacia de las sinapsis podr\u00eda determinar el establecimiento de conexiones espec\u00edficas durante el desarrollo. Por todo ello, se estudiaron distintos aspectos de la plasticidad sin\u00e1ptica a corto y a largo plazo en el hipocampo de ratas hipotiroideas, empleando para ello distintas t\u00e9cnicas electrofisiol\u00f3gicas.  la plasticidad a corto plazo se evalu\u00f3 en ratas neonatales mediante el estudio de la facilitaci\u00f3n por par de pulsos (ppf), la aumentaci\u00f3n, la potenciaci\u00f3n post-tet\u00e1nica (ptp) y la depresi\u00f3n inducida por estimulaci\u00f3n repetitiva. La ppf result\u00f3 profundamente reducida en los animales hip\u00f3tiroideos, lo que llev\u00f3 a la realizaci\u00f3n de otros experimentos que revelaron una mayor probabilidad de liberaci\u00f3n de neurotransmisor en estos animales. Ambos par\u00e1metros volvieron a valores normales cuando se administr\u00f3 a los animales hipotiroideos un tratamiento con t3. Tambi\u00e9n la aumentaci\u00f3n resulto disminuida por el hipotiroidismo. Sin embargo, la ptp y la depresi\u00f3n por estimulaci\u00f3n repetitiva no mostraron alteraciones.  ninguno de los cuatro tipos de plasticidad a largo plazo que se estudiaron (potenciaci\u00f3n a largo plazo (ltp), depresi\u00f3n a largo plazo (ltd), depotenciaci\u00f3n y de-depresi\u00f3n) result\u00f3 afectado por el hipotiroidismo en ratas neonatales. sin embargo, puesto que esta plasticidad experimenta cambios durante el desarrollo, se estudi\u00f3 tambi\u00e9n en animales hipotiroideos adultos, en los que se encontr\u00f3 un incremento en la magnitud de la depresi\u00f3n a largo plazo (ltd) y en la de-depresi\u00f3n con respe<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del hipotiroidismo sobre la plasticidad sin\u00e1ptica en el hipocampo de rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del hipotiroidismo sobre la plasticidad sin\u00e1ptica en el hipocampo de rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Hugo Vara Rivera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Asunci\u00f3n Colino Matilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 S\u00e1nchez-prieto borja <\/li>\n<li>alfonso Araque almendros (vocal)<\/li>\n<li> Sol\u00eds torralba Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Rafael Fern\u00e1ndez chac\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hugo Vara Rivera La deficiencia de hormona tiroidea (t3) durante un per\u00edodo cr\u00edtico del desarrollo afecta profundamente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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